|
Cat. No. |
MMP24-610H |
|
Product Overview |
Recombinant Human MMP17 was produced
in E.coli.
Activation generates two molecular species. One species begins at
the N-terminus with Tyr156 of full-length MMP-24, while the other
species is two aa residues shorter and starts with Leu158. Both
species extend to Ser351 of MMP-24 and contain an additional His-tag
sequence at the C-terminus. |
|
Description |
Proteins of the
matrix metalloproteinase (MMP) family are involved in the breakdown
of extracellular matrix in normal physiological processes, such as
embryonic development, reproduction, and tissue remodeling, as well
as in disease processes, such as arthritis and metastasis. Most
MMP's are secreted as inactive proproteins which are activated when
cleaved by extracellular proteinases. However, the protein encoded
by this gene is a member of the membrane-type MMP (MT-MMP)
subfamily; each member of this subfamily contains a potential
transmembrane domain suggesting that these proteins are expressed at
the cell surface rather than secreted. This protein activates MMP2
by cleavage. The gene has previously been referred to as MMP25 but
has been renamed MMP24. |
|
Source |
E. coli. |
|
Purity |
≥90% (SDS-PAGE). |
|
Formulation |
Liquid. In 50mM
TRIS-HCl, pH 7.5, containing 150mM NaCl and 5mM CaCl2. |
|
Concentration |
0.2mg/ml. |
|
Specific Activity |
≥120mU/mg protein.
One unit is defined as the amount of enzyme that hydrolyzes 1µmol
Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 per
min. at 37°C, pH 7.5. |
|
Storage |
Store at -80℃. |
|
Gene Information
|
Gene Name |
MMP24 matrix metallopeptidase 24 (membrane-inserted) [ Homo sapiens
] |
|
Synonyms
|
MMP24; matrix
metallopeptidase 24 (membrane-inserted); MMP25; MT-MMP5; MT5-MMP;
matrix metalloproteinase-24; MMP-24; MT5MMP; MTMMP5; MT-MMP 5;
membrane-type 5 matrix metalloproteinase; membrane-type matrix
metalloproteinase 5; membrane-type-5 matrix metalloproteinase;
Matrix metalloproteinase-24; EC 3.4.24.-; Processed matrix
metalloproteinase-24; matrix
metalloproteinase 24 (membrane-inserted) |
|
GeneID |
10893 |
|
mRNA Refseq |
NM_006690 |
|
Protein Refseq |
NP_006681 |
|
MIM |
604871 |
|
UniProt ID |
Q9Y5R2 |
|
Chromosome Location |
20q11.2 |
|
Function |
calcium ion
binding; enzyme activator activity; metalloendopeptidase activity;
peptidase activity; zinc ion binding |
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