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Discription |
Nuclear factor
of kappa light polypeptide gene enhancer in B-cells 1 (p105),
also known as NFKB1 or p50, is a human gene. This gene encodes a
105 kD protein which can undergo cotranslational processing by
the 26S proteasome to produce a 50 kD protein. The 105 kD
protein is a Rel protein-specific transcription inhibitor and
the 50 kD protein is a DNA binding subunit of the NF-kappaB (NF-κB)
protein complex. NF-κB is a transcription factor that is
activated by various intra- and extra-cellular stimuli such as
cytokines, oxidant-free radicals, ultraviolet irradiation, and
bacterial or viral products. Activated NF-κB translocates into
the nucleus and stimulates the expression of genes involved in a
wide variety of biological functions; over 200 known genes are
targets of NF-κB in various cell types, under specific
conditions. Inappropriate activation of NF-κB has been
associated with a number of inflammatory diseases while
persistent inhibition of NF-κB leads to inappropriate immune
cell development or delayed cell growth. |
