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Cat. No. |
NEIL2-586H |
|
Product Overview |
Recombinant human
NEIL2 was expressed in and purified from E. coli. |
|
Description |
NEIL2 is a DNA
glycosylase involved in base excision repair of oxidative DNA
damage. It is a member of the Fpg/Nei/NEIL family of bi-functional
DNA glycosylases. Following its glycosylase action, NEIL2 catalyzes
sequential β-elimination and δ-elimination reactions via its
associated AP lyase. This results in a one-nucleotide gap in DNA
containing a 3’ phosphate group. A phosphatase is needed to remove
the 3’phosphate group before DNA repair synthesis can occur. |
|
Source |
E. coli. |
|
Purity |
Apparent
homogeneity by SDS-PAGE and Coomassie blue staining. |
|
Formulation |
20 mM Tris-HCl, pH
7.5, 300 mM NaCl, 10% glycerol. |
|
Storage |
Store at -70℃.
Aliquot to avoid repeated freezing and thawing. |
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Gene Information
|
Gene Name |
NEIL2 nei endonuclease VIII-like 2 (E. coli) [ Homo sapiens ] |
|
Synonyms
|
NEIL2; nei
endonuclease VIII-like 2 (E. coli); NEH2; NEI2; MGC2832; MGC4505;
FLJ31644; nei like 2; EC 4.2.99.18; DNA glycosylase/AP lyase Neil2;
DNA-(apurinic or apyrimidinic site) lyase Neil2; Nei-like protein 2;
Nei homolog 2; Nei-like 2 |
|
GeneID |
252969 |
|
mRNA Refseq |
NM_001135746 |
|
Protein Refseq |
NP_001129218 |
|
MIM |
608933 |
|
UniProt ID |
Q969S2 |
|
Chromosome Location |
8p23.1 |
|
Pathway |
Base excision
repair |
|
Function |
DNA-(apurinic or
apyrimidinic site) lyase activity; damaged DNA binding; hydrolase
activity, hydrolyzing N-glycosyl compounds; lyase activity; metal
ion binding; microtubule binding; zinc ion binding |
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Abbr.: 
