|
Cat. No. |
BCL2L1-1851H |
|
Product Overview |
Recombinant Human
BCL-X cloned from human cDNA was expressed in E. coli.MW=28kDa. |
|
Description |
Bcl-2-like protein
1 is a protein that in humans is encoded by the BCL2L1 gene.The
protein encoded by this gene belongs to the BCL-2 protein family.
BCL-2 family members form hetero- or homodimers and act as anti- or
pro-apoptotic regulators that are involved in a wide variety of
cellular activities. The proteins encoded by this gene are located
at the outer mitochondrial membrane, and have been shown to regulate
outer mitochondrial membrane channel (VDAC) opening. VDAC regulates
mitochondrial membrane potential, and thus controls the production
of reactive oxygen species and release of cytochrome C by
mitochondria, both of which are the potent inducers of cell
apoptosis. Two alternatively spliced transcript variants, which
encode distinct isoforms, have been reported. The longer isoform
acts as an apoptotic inhibitor and the shorter form acts as an
apoptotic activator. |
|
Source |
E.Coli. |
|
Purity |
>90%. |
|
Application |
Useful for the
study of apoptosis, screening inhibitors, and selectivity profiling. |
|
Formulated In |
25 mM Tris-HCl, pH
8.0, 100 mM NaCl, 0.05% Tween-20, 30% glycerol, and 3 mM DTT. |
|
Stability |
>6 months at –80°C. |
|
Gene Information
|
Gene Name |
BCL2L1 BCL2-like 1 [ Homo sapiens ] |
|
Synonyms
|
BCL2L1; BCL2-like
1; BCLX; BCL2L; Bcl-X; bcl-xL; bcl-xS; BCL-XL/S; DKFZp781P2092;
OTTHUMP00000030550; Bcl-2-like protein 1; Bcl2-L-1; Apoptosis
regulator Bcl-X; OTTHUMP00000030551; OTTHUMP00000030553; bcl-xL;
bcl-xS; Apoptosis regulator Bcl-X |
|
GeneID |
598 |
|
mRNA Refseq |
NM_001191 |
|
Protein Refseq |
NP_001182 |
|
MIM |
600039 |
|
UniProt ID |
Q07817 |
|
Chromosome Location |
20q11.21 |
|
Pathway |
Amyotrophic lateral
sclerosis (ALS); Apoptosis; Chronic myeloid leukemia; Jak-STAT
signaling pathway; Pancreatic cancer; Pathways in cancer; Small cell
lung cancer; Apoptosis |
|
Function |
caspase inhibitor
activity; identical protein binding; protein heterodimerization
activity |
|
PDB rendering based on 1af3.
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Download Datasheet:
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Abbr.: 
