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Cat. No. |
KHK-491H
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Product Overview |
Recombinant human
Ketohexokinase was expressed in E.coli and purified by using
conventional chromatography. |
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Description |
Ketohexokinase is
an enzyme that catalyzes the phosphorylation of fructose to produce
fructose-1-phosphate, leading to consumption of ATP, formation of
AMP. This protein initiates first step in the metabolism of dietary
fructose and is an important regulator of hepatic glucose
metabolism. It is highly found in liver, renal cortex, and small
intestine. Its deficiency causes the benign hereditary metabolic
disorder essential fructosuria, leading to fructose being excreted
in the urine. |
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Sequences of amino
acids |
MEEKQILCVG
LVVLDVISLV DKYPKEDSEI RCLSQRWQRG GNASNSCTIL SLLGAPCAFM GSMAPGHVAD
FVLDDLRRYS VDLRYTVFQT TGSVPIATVI INEASGSRTI LYYDRSLPDV SATDFEKVDL
TQFKWIHIEG RNASEQVKML QRIDAHNTRQ PPEQKIRVSV EVEKPREELF QLFGYGDVVF
VSKDVAKHLG FQSAEEALRG LYGRVRKGAV LVCAWAEEGA DALGPDGKLL HSDAFPPPRV
VDTLGAGDTF NASVIFSLSQ GRSVQEALRF GCQVAGKKCG LQGFDGIV |
|
Form |
Liquid. In
Phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol |
|
Molecular Weight |
32.7 kDa (298aa) |
|
Purity |
> 90% by SDS -
PAGE |
|
Concentration |
1 mg/ml (determined
by Bradford assay) |
|
Storage |
Can be stored at
+4°C short term (1-2 weeks). For long term storage, aliquot and
store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
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Gene Information
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Gene Name |
KHK ketohexokinase (fructokinase) [ Homo sapiens ] |
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Synonyms
|
KHK; ketohexokinase
(fructokinase); ketohexokinase; EC 2.7.1.3; ketohexokinase; Hepatic
fructokinase; |
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GeneID |
3795 |
|
mRNA Refseq |
NM_000221 |
|
Protein Refseq |
NP_000212 |
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MIM |
229800 |
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UniProt ID |
P50053 |
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Chromosome Location |
2p23.3 |
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Pathways |
Fructose and
mannose metabolism; Metabolic pathways; Metabolism of carbohydrates |
|
Function |
ATP binding;
ketohexokinase
activity; kinase activity; nucleotide binding; protein binding;
transferase activity |
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Download Datasheet:
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