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Cat. No. |
PDE11A-441H |
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Product Overview |
Recombinant Human PDE11A, full length with N-terminal GST
tag expressed in a Baculovirus infected Sf9 cell expression
system. MW = 131kDa. |
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Description |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A is an
enzyme that in humans is encoded by the PDE11A gene. The
3',5'-cyclic nucleotides cAMP and cGMP function as second
messengers in a wide variety of signal transduction
pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs)
catalyze the hydrolysis of cAMP and cGMP to the
corresponding 5'-monophosphates and provide a mechanism to
downregulate cAMP and cGMP signaling. This gene encodes a
member of the PDE protein superfamily. Mutations in this
gene are a cause of Cushing disease and adrenocortical
hyperplasia. Multiple transcript variants encoding different
isoforms have been found for this gene. |
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Source |
Sf9 cell. |
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Purity |
>80%. |
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Application |
Useful for the study of enzyme kinetics, screening
inhibitors, and selectivity profiling. |
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Formulated In |
25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 30%
glycerol, and 3 mM DTT. |
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Stability |
>6 months at –80°C. |
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Gene Information
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Gene Name |
PDE11A phosphodiesterase 10A [ Homo sapiens ] |
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Synonyms |
PDE11A; phosphodiesterase 11A; PPNAD2; FLJ23693; MGC133355;
MGC133356; EC 3.1.4.17; EC 3.1.4.35; OTTHUMP00000205272;
cAMP and cGMP cyclic nucleotide phosphodiesterase 11A;
cyclic nucleotide phosphodiesterase 11A; dual
3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
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GeneID |
50940 |
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mRNA Refseq |
NM_001077196 |
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Protein Refseq |
NP_001070664 |
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MIM |
604961 |
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UniProt ID |
Q9HCR9 |
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Chromosome Location |
2q31.2 |
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Pathway |
Progesterone-mediated oocyte maturation; Purine metabolism;
Signaling by GPCR |
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Function |
3',5'-cyclic-GMP phosphodiesterase activity; cAMP binding;
cGMP binding; hydrolase activity; magnesium ion binding |
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