Recombinant Rat Interleukin 15   [ Back  ]                         Price Inquiry

Cat. No.

Il15-231R

Description

Interleukin 15 (IL-15) is a novel cytokine that uses beta- and gamma-chain of IL-2R for signal transduction and is structurally similarity to IL-2. IL-15 is secreted by activated monocytes/macrophages following infection by virus. This cytokine induces cell proliferation of natural killer cells. This cytokine and interleukin 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. IL-15 can recruit and activate T lymphocytes in the synovial membrane, thereby contributing to Rheumatoid arthritis pathogenesis.

Source

Sf 21 Insect Cells.

Molecular Weight

The predicted molecular weight of Recombinant Rat IL-15 is Mr 70 kDa.

State Of Matter

Lyophilized.

Purity

>95% by SDS Page and HPLC.

Endotoxin

<1.0 EU/µg.

Storage And Stability

The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Gene Information

Gene Name

Il15 interleukin 15 [ Rattus norvegicus ]

Synonyms

Il15; interleukin 15

GeneID

25670

mRNA Refseq

NM_013129

Protein Refseq

NP_037261

UniProt ID

P97604

Chromosome Location

19q11

Pathway

Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway

Function

cytokine activity; molecular_function; protein binding