|
Cat. No. |
Icos-1747M |
|
Description |
Inducible
co-stimulator (ICOS) is an inducible homodimeric costimulator
protein that is structurally and functionally related to CD28. It is
a third member of the CD28/CTLA4 family and it is expressed on
activated T cells. ICOS regulates CD28-dependent and
CD28-independent CD4 (+) subset (Th1 and Th2) responses. ICOS is a
major regulator of the adaptive immune system and therefore, has a
protective role in inflammatory autoimmune diseases. |
|
Molecular Weight |
The predicted
molecular weight of Recombinant Mouse ICOS is Mr 44 kDa. However,
the actual molecular weight as observed by migration on SDS Page is
Mr 47 kDa. |
|
Source |
Sf 21 Insect Cells. |
|
State Of Matter |
Lyophilized. |
|
Purity |
>95% by SDS Page
and analyzed by silver stain. |
|
Endotoxin |
<1.0 EU/µg as determined by the LAL
method。 |
|
Storage And
Stability |
This lyophilized
protein is stable for six to twelve months when stored desiccated at
-20℃ to -70℃.
After aseptic reconstitution, this protein may be stored at 2℃
to 8℃ for one
month or at -20℃
to -70℃ in a
manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See
Product Insert for exact lot specific storage instructions. |
|
Gene Information
|
Gene Name |
Icos inducible T-cell co-stimulator [ Mus musculus ] |
|
Synonyms
|
Icos; inducible
T-cell co-stimulator; H4; AILIM; Ly115; OTTMUSP00000002206 |
|
GeneID |
54167 |
|
mRNA Refseq |
NM_017480 |
|
Protein Refseq |
NP_059508 |
|
UniProt ID |
Q9WVS0 |
|
Chromosome Location |
1 C2; 1 32.0 cM |
|
Pathway |
Cell adhesion
molecules (CAMs); Primary immunodeficiency; T cell receptor
signaling pathway |
|
Function |
protein binding |
|
|
Download Datasheet:
|
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Abbr.: 
