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Cat. No. |
DNMT1-511H
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Product Overview |
Recombinant Human DNMT1, (a-a 2-1632),
with N-terminal GST tag expressed in baculovirus. MW=
211 kDa. |
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Description |
DNA
(cytosine-5-)-methyltransferase 1 has a role in the establishment
and regulation of tissue-specific patterns of methylated cytosine
residues. Aberrant methylation patterns are associated with certain
human tumors and developmental abnormalities. |
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Source |
Baculovirus. |
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Purity |
>50%. |
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Application |
Useful for the
study of enzyme kinetics, screening inhibitors, and selectivity
profiling. |
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Formulated In |
25 mM Tris-HCl, pH
8.0, 100 mM NaCl, 0.05% Tween-20 and 10% glycerol. |
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Stability |
>6 months at –80°C. |
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Gene Information
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Gene Name |
DNMT1 DNA (cytosine-5-)-methyltransferase 1 [ Homo sapiens ] |
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Synonyms
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DNMT1; DNA
(cytosine-5-)-methyltransferase 1; AIM; DNMT; MCMT; CXXC9; FLJ16293;
MGC104992; CXXC finger protein 9; DNA methyltransferase 1; EC
2.1.1.37; Dnmt1; DNA methyltransferase
HsaI; DNA MTase HsaI; M.HsaI; CXXC-type zinc finger protein 9 |
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GeneID |
1786 |
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mRNA Refseq |
NM_001130823 |
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Protein Refseq |
NP_001124295 |
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MIM |
126375 |
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UniProt ID |
P26358 |
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Chromosome Location |
19p13.2 |
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Pathway |
Cysteine and
methionine metabolism; Metabolic pathways |
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Function |
DNA (cytosine-5-)-methyltransferase
activity; DNA binding; metal ion binding; transcription factor
binding; transferase activity; zinc ion binding
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Download Datasheet:
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