Recombinant Human DDR1, GST-tagged   [ Back  ]                         Price Inquiry

Cat. No.

DDR1-509H 

Product Overview

Recombinant Human DDR1, (amino acids 444 – end) with N-terminal GST tag expressed in Baculovirus infected Sf9 cell expression system. MW= 76 kDa.

Description

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.

Source

Baculovirus infected Sf9 cell.

Purity

>80%.

Application

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Formulated In

50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 50% glycerol and 3mM DTT.

Stability

>12 months at –80°C.

Gene Information

Gene Name

DDR1 discoidin domain receptor tyrosine kinase 1 [ Homo sapiens ]

Synonyms

DDR1; discoidin domain receptor tyrosine kinase 1; DAAP-278B20.1; CAK; CD167; DDR; EDDR1; MCK10; NEP; NTRK4; PTK3; PTK3A; RTK6; TRKE; OTTHUMP00000029344; OTTHUMP00000029345; OTTHUMP00000029346; OTTHUMP00000029347; PTK3A protein tyrosine kinase 3A; cell adhesion kinase; discoidin domain receptor family, member 1; discoidin receptor tyrosine kinase; epithelial discoidin domain receptor 1; mammarian carcinoma kinase 10; neuroepithelial tyrosine kinase; neurotrophic tyrosine kinase, receptor, type 4; EC 2.7.10.1

GeneID

780

mRNA Refseq

NM_001954

Protein Refseq

NP_001945

MIM

600408

UniProt ID

Q08345

Chromosome Location

6p21.3

Function

ATP binding; nucleotide binding; protein binding; receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity