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Cat. No. |
CARM1-451H
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Product Overview |
Recombinant Human
PRMT4, amino-acids 2-end expressed in a FreeStyle 293-F cells
expression system. MW= 66 kDa. |
|
Description |
CARM1 (coactivator-associated
arginine methyltransferase 1) is an enzyme encoded by the CARM1
gene found in human beings, as well as many other mammals. CARM1 is
a secondary coactivator through its association with p160 family
(SRC-1, GRIP1, AIB) of coactivators. It is responsible for moving
cells toward the inner cell mass in developing blastocysts. This
gene also plays an important role in androgen receptors and may play
a role in prostate cancer progression. |
|
Source |
FreeStyle 293-F
cells. |
|
Purity |
>60%. |
|
Application |
Useful for the
study of enzyme kinetics, screening inhibitors, and selectivity
profiling. |
|
Formulated In |
25 mM Tris-HCl, pH
8.0, 100 mM NaCl, 0.05% Tween-20, 50% glycerol, and 3 mM DTT. |
|
Stability |
>6 months at –80°C. |
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Gene Information
|
Gene Name |
CARM1 coactivator-associated arginine methyltransferase 1 [ Homo
sapiens ] |
|
Synonyms
|
CARM1;
coactivator-associated arginine methyltransferase 1; PRMT4;
EC 2.1.1.125; 3` partial; protein arginine
N-methyltransferase 4; Histone-arginine methyltransferase CARM1;
EC
2.1.1.-; Protein
arginine N-methyltransferase 4; Coactivator-associated arginine
methyltransferase 1 |
|
GeneID |
10498 |
|
mRNA Refseq |
NM_199141 |
|
Protein Refseq |
NP_954592 |
|
MIM |
603934 |
|
UniProt ID |
Q86X55 |
|
Chromosome Location |
19p13.2 |
|
Pathway |
Metabolism of
lipids and lipoproteins |
|
Function |
histone-arginine
N-methyltransferase activity; transferase activity; protein binding;
transcription coactivator activity; protein methyltransferase
activity |
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Download Datasheet:
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Abbr.: 
