|
Cat. No. |
Agrn-1789R |
|
Description |
Agrin is a large
proteoglycan whose best characterised role is in the development of
the neuromuscular junction during embryogenesis. Agrin is named
based on its involvement in the aggregation of acetylcholine
receptors during synaptogenesis. In humans, this protein is encoded
by the AGRIN gene. This protein has nine domains homologous to
protease inhibitors. It may also have functions in other tissues and
during other stages of development. It is major proteoglycan
component in glomerular basement membrane and may play a role in the
renal filtration and cell-matrix interactions. |
|
Molecular Weight |
The predicted
molecular weight of Recombinant Rat Agrin (C-Terminal) is Mr 90 kDa.
However, the actual molecular weight as observed by migration on SDS
Page is Mr 100 kDa. |
|
Source |
Sf 21 Insect Cells. |
|
State Of Matter |
Lyophilized. |
|
Purity |
>90% by SDS Page
and analyzed by silver stain. |
|
Endotoxin |
<1.0 EU/µg as
determined by the LAL method. |
|
Storage And
Stability |
This lyophilized
protein is stable for six to twelve months when stored desiccated at
-20℃ to -70℃.
After aseptic reconstitution, this protein may be stored at 2℃
to 8℃ for one
month or at -20℃
to -70℃ in a
manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See
Product Insert for exact lot specific storage instructions. |
|
Gene Information
|
Gene Name |
Agrn agrin [ Rattus norvegicus ] |
|
Synonyms
|
Agrn; agrin;
AGR |
|
GeneID |
25592 |
|
mRNA Refseq |
NM_175754 |
|
Protein Refseq |
NP_786930 |
|
UniProt ID |
P25304 |
|
Chromosome Location |
5q36 |
|
Pathway |
ECM-receptor
interaction |
|
Function |
acetylcholine
receptor regulator activity; laminin binding |
|
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Abbr.: 
