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Cat. No. |
ACLY-420H |
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Product Overview |
Recombinant Human
ATP citrate lyase (ACLY), full length, with Nterminal GST tag,
MW=147 kDa, expressed in baculovirus expression system. |
|
Description |
ATP citrate lyase
is the primary enzyme responsible for the synthesis of cytosolic
acetyl-CoA in many tissues. The enzyme is a tetramer of apparently
identical subunits. The product, acetyl-CoA, serves several
important biosynthetic pathways, including lipogenesis and
cholesterogenesis. It is activated in by insulin. |
|
Source |
Baculovirus. |
|
Formulated In |
25 mM Tris-HCl, pH
8.0, 100 mM NaCl, 0.05% Tween-20 and 10% glycerol. |
|
Purity |
>90%. |
|
Application |
Useful for the
study of enzyme kinetics, screening inhibitors, and selectivity
profiling. |
|
Stability |
>6 months at -80℃. |
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Gene Information
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Gene Name |
ACLY ATP citrate lyase [ Homo sapiens ] |
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Synonyms
|
ACLY; ATP citrate
lyase; ACL; ATPCL; CLATP; OTTHUMP00000164773; EC 2.3.3.8;
ATP-citrate synthase; ATP-citrate (pro-S-)-lyase; Citrate cleavage
enzyme |
|
GeneID |
47 |
|
mRNA Refseq |
NM_001096 |
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Protein Refseq |
NP_001087 |
|
MIM |
108728 |
|
UniProt ID |
P53396 |
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Chromosome Location |
17q12-q21 |
|
Pathway |
Citrate cycle (TCA
cycle); Metabolic pathways |
|
Function |
ATP binding; ATP
citrate synthase activity; citrate (pro-3S)-lyase activity;
magnesium ion binding; nucleotide binding; protein binding;
succinate-CoA ligase (ADP-forming) activity; transferase activity
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