|
Cat. No. |
NBL1-1599H |
|
Description |
DAN is a secreted glycoprotein related to Xenopus laevis
cerberus. It is being referred to also as DAND1 [DAN domain
family member 1]. The gene has been described also as NO3
gene, which shows tumor suppressor activity in cells
transformed by the src oncogene. DAN belongs to a gene
family, termed CAN family, that includes the head-inducing
factor Gremlin, Cerberus, PRDC. DAN and several other
members of the can family act as antagonists of BMP and
appear to block BMP signaling by preventing bone
morphogenetic proteins from interacting with their
receptors. DAN has recently been demonstrated to have a
tumor-suppressive activity in vitro and may have an
important role in regulation of the entry of cells into the
S phase. |
|
Molecular Weight |
The predicted molecular weight of Recombinant Human DAN is
Mr 44.3 kDa. However, the actual molecular weight as
observed by migration on SDS Page is Mr 55-65 kDa. |
|
Source |
NSO Cells. |
|
State Of Matter |
Lyophilized. |
|
Purity |
>95% by SDS Page and analyzed by silver stain. |
|
Endotoxin |
<1.0 EU/µg as determined by the LAL method. |
|
Storage And Stability |
This lyophilized protein is stable for six to twelve months
when stored desiccated at -20°C to -70°C. After aseptic
reconstitution, this protein may be stored at 2°C to 8°C for
one month or at -20°C to -70°C in a manual defrost freezer.
Avoid Repeated Freeze Thaw Cycles. See Product Insert for
exact lot specific storage instructions. |
|
Gene Information
|
Gene Name |
NBL1 neuroblastoma, suppression of tumorigenicity 1 [ Homo
sapiens ] |
|
Synonyms |
NBL1; neuroblastoma, suppression of tumorigenicity 1; NB;
DAN; NO3; DAND1; MGC8972; D1S1733E; neuroblastoma suppressor
of tumorigenicity 1; differential screening-selected gene
aberrant in neuroblastoma; neuroblastoma candidate region,
suppression of tumorigenicity 1; Neuroblastoma suppressor of
tumorigenicity 1; Zinc finger protein DAN; DAN domain family
member 1 |
|
GeneID |
4681 |
|
mRNA Refseq |
NM_005380 |
|
Protein Refseq |
NP_005371 |
|
MIM |
600613 |
|
UniProt ID |
P41271 |
|
Chromosome Location |
1p36.3-p36.2 |
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Abbr.: 
