|
Cat. No. |
Dcc-1718M |
|
Description |
Deleted in Colorectal Carcinoma, also known as DCC is a
tumor suppressor gene found in axons of the central and
peripheral nervous system and in differentiated cell types
of the intestine. DCC may participate in signaling pathways
that regulate cell proliferation and/or differentiation, two
cellular processes that often go awry during tumorigenesis.
DCC is required for the formation of major axonal
projections by embryonic cortical neurons, including the
corpus callosum, hippocampal commissure, and cortico-thalamic
tracts. |
|
Molecular Weight |
The predicted molecular weight of Recombinant Mouse DCC is
Mr 146 kDa. However, the actual molecular weight as observed
by migration on SDS Page is Mr 160-170 kDa. |
|
Source |
Sf 21 Insect Cells. |
|
State Of Matter |
Lyophilized. |
|
Purity |
>90% by SDS Page and analyzed by silver stain. |
|
Endotoxin |
<1.0 EU/µg as determined by the LAL method. |
|
Storage And Stability |
This lyophilized protein is stable for six to twelve months
when stored desiccated at -20℃ to -70℃. After aseptic
reconstitution, this protein may be stored at 2℃ to 8℃ for
one month or at -20℃ to -70℃ in a manual defrost freezer.
Avoid Repeated Freeze Thaw Cycles. See Product Insert for
exact lot specific storage instructions. |
|
Gene Information
|
Gene Name |
Dcc deleted in colorectal carcinoma [ Mus musculus ] |
|
Synonyms |
Dcc; deleted in colorectal carcinoma; Igdcc1; C030036D22Rik;
netrin receptor DCC; OTTMUSP00000024718 |
|
GeneID |
13176 |
|
mRNA Refseq |
NM_007831 |
|
Protein Refseq |
NP_031857 |
|
UniProt ID |
P70211 |
|
Chromosome Location |
18 E2; 18 45.0 cM |
|
Pathway |
Axon guidance; Colorectal cancer; Pathways in cancer |
|
Function |
receptor activity |
|
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Abbr.: 
