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Cat. No. |
XIAP-1503H |
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Product Overview |
Recombinant full-length human XIAP was expressed by
baculovirus in Sf9 insect cells using a C-terminal GST tag.
MW = 84 kDa. |
|
Description |
XIAP is a member of a family of proteins which inhibit
apoptosis and act as mammalian cell-death suppressors. XIAP
inhibits at least 2 members of the caspase family of
cell-death proteases, caspase-3 and caspase-7. In addition,
XIAP inhibits apoptosis induced by menadione, a potent
inducer of free radicals, and ICE. Furthermore, XIAP can
mediate protection of cells from apoptosis by utilizing both
a JNK1 activation pathway that involves ILPIP and a caspase
inhibition pathway that is independent of ILPIP. Disruption
of the XIAP gene in human colon cancer cells can enhance
sensitivity of these cells to exogenously added TRAIL
suggesting that XIAP is a nonredundant modulator of
TRAIL-mediated apoptosis. |
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Source |
Sf9 insect cells using baculovirus.
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|
Sequence |
Full-length. |
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Applications |
Western Blot. |
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Storage And Stability |
Store product at -70℃. For optimal storage, aliquot target
into smaller quantities after centrifugation and store at
recommended temperature. For most favorable performance,
avoid repeated handling and multiple freeze/thaw cycles. |
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Gene Information
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Gene Name |
XIAP X-linked inhibitor of apoptosis [ Homo sapiens ] |
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Synonyms |
XIAP; X-linked inhibitor of apoptosis; API3; ILP1; MIHA;
XLP2; BIRC4; baculoviral IAP repeat-containing protein 4;
OTTHUMP00000196392; apoptosis inhibitor 3; baculoviral IAP
repeat-containing 4; E3 ubiquitin-protein ligase XIAP;
Inhibitor of apoptosis protein 3; X-linked inhibitor of
apoptosis protein; X-linked IAP; IAP-like protein; HILP;
IAP3; EC 6.3.2.-; OTTHUMP00000023975; hILP |
|
GeneID |
331 |
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mRNA Refseq |
NM_001167 |
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Protein Refseq |
NP_001158 |
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MIM |
300079 |
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UniProt ID |
P98170 |
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Chromosome Location |
Xq25 |
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Pathway |
Apoptosis; Focal adhesion; NOD-like receptor signaling
pathway; Pathways in cancer; Small cell lung cancer;
Ubiquitin mediated proteolysis |
|
Function |
caspase inhibitor activity; ligase activity; metal ion
binding; peptidase inhibitor activity; protein binding; zinc
ion binding |
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PDB rendering based on 1c9q.
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