|
Cat. No. |
KAT2B-1481H |
|
Product Overview |
Recombinant human PCAF (431-end) was expressed in E. coli
cells using a N-terminal GST tag. MW = 69 kDa. |
|
Description |
PCAF is a protein that shows homology to the yeast GCN5 and
associates with p300/CBP. PCAF has in vitro and in vivo
binding activity with CBP and p300, and competes with E1A
for binding sites in p300/CBP. PCAF encodes a predicted
832-amino acid protein that showed by RNA blotting to be
expressed in all tissues, most strongly in heart and
skeletal muscle. PCAF has histone acetyl transferase
activity with core histones and nucleosome core particles,
indicating that this protein plays a direct role in
transcriptional regulation. PCAF is required for MyoD
activity and muscle differentiation. PCAF directly
acetylated MyoD which then displays an increased affinity
for its DNA target. |
|
Source |
E. coli. |
|
Sequence |
431-end. |
|
Applications |
Kinase Assay, Western Blot. |
|
Storage And Stability |
Store product at -70℃. For optimal storage, aliquot target
into smaller quantities after centrifugation and store at
recommended temperature. For most favorable performance,
avoid repeated handling and multiple freeze/thaw cycles. |
|
Gene Information
|
Gene Name |
KAT2B K(lysine) acetyltransferase 2B [ Homo sapiens ] |
|
Synonyms |
KAT2B; K(lysine) acetyltransferase 2B; P; CAF; PCAF; P/CAF;
CREBBP-associated factor; p300/CBP-associated factor;
Histone acetyltransferase KAT2B; EC 2.3.1.48; Lysine
acetyltransferase 2B; Histone acetylase PCAF; P300/CBP-associated
factor; P/CAF; GCN5; GCN5L |
|
GeneID |
8850 |
|
mRNA Refseq |
NM_003884 |
|
Protein Refseq |
NP_003875 |
|
MIM |
602303 |
|
UniProt ID |
Q92831 |
|
Chromosome Location |
3p24 |
|
Pathway |
Notch signaling pathway; Gene Expression; Transcription |
|
Function |
histone acetyltransferase activity; histone deacetylase
binding; transcription coactivator activity; transferase
activity |
|
PDB rendering based on 1cm0.
|
Download Datasheet:
|
|
Abbr.: 
