Recombinant Human Heme Oxygenase (Decycling) 2, GST-tagged   [ Back  ]                         Price Inquiry

Cat. No.

HMOX2-1453H

Product Overview

Recombinant full-length human HO2 Protein was expressed in E. coli cells using an N-terminal GST tag. MW = 62 kDa.

Description

HO2, or heme oxygenase 2, belongs to the heme oxygenase family that are essential enzyme in heme catabolism that cleave heme to form biliverdin which is subsequently converted to bilirubin by biliverdin reductase. HO2 is part of the calcium-sensitive potassium channel complex and enhances channel activity in normoxia. Knockdown of HO2 expression reduces channel activity, an effect that is reversed by carbon monoxide. Inhibition of calcium-sensitive potassium channels by hypoxia is dependent on HO2 expression and is augmented by HO2 stimulation.

Source

E. coli.

Sequence

Full-length.

Applications

Western Blot.

Storage And Stability

Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

Gene Name

HMOX2 heme oxygenase (decycling) 2 [ Homo sapiens ]

Synonyms

HMOX2; heme oxygenase (decycling) 2; HO-2; EC 1.14.99.3; HO2; heme oxygenase (decyclizing) 2; Heme oxygenase 2

GeneID

3163

mRNA Refseq

NM_001127204

Protein Refseq

NP_001120676

MIM

141251

UniProt ID

P30519

Chromosome Location

16p13.3

Pathway

Porphyrin and chlorophyll metabolism

Function

electron carrier activity; heme oxygenase (decyclizing) activity; iron ion binding; metal ion binding; oxidoreductase activity; protein binding