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Cat. No. |
BAG1-1434H |
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Product Overview |
Recombinant human BAG1 (72-end) was expressed in E. coli
cells using an N-terminal GST tag. MW = 66kDa. |
|
Description |
BAG1 (also known as BCL2-associated athanogene) is a
membrane protein rich in glutamic acid residues that binds
to BCL2 and blocks apoptosis or programmed cell death. The
BAG1-BCL2 complex enhances the anti-apoptotic effects of
BCL2 and represents a link between growth factor receptors
and anti-apoptotic mechanisms. Overexpression of BAG1 in 3T3
fibroblasts prevents apoptosis in the presence of low serum.
BAG1 has also been shown to interact with activated
glucocorticoid, androgen, estrogen and progesterone
receptors. Binding to these receptors by BAG1 is dependent
on receptor activation. |
|
Source |
E. coli. |
|
Sequence |
72-end. |
|
Applications |
Western Blot. |
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Storage And Stability |
Store product at -70℃. For optimal storage, aliquot target
into smaller quantities after centrifugation and store at
recommended temperature. For most favorable performance,
avoid repeated handling and multiple freeze/thaw cycles. |
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Gene Information
|
Gene Name |
BAG1 BCL2-associated athanogene [ Homo sapiens ] |
|
Synonyms |
BAG1; BCL2-associated athanogene; RAP46; BAG-1; HAP;
BCL2-associated athanogene 1; Bcl-2-associated athanogene 1;
Glucocorticoid receptor-associated protein RAP46 |
|
GeneID |
573 |
|
mRNA Refseq |
NM_004323 |
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Protein Refseq |
NP_004314 |
|
MIM |
601497 |
|
UniProt ID |
Q99933 |
|
Chromosome Location |
9p12 |
|
Function |
protein binding; receptor signaling protein activity |
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PDB rendering based on 1hx1.
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Download Datasheet:
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Abbr.: 
