|
Cat. No. |
PDE7A-481H |
|
Product Overview |
Recombinant human PDE7A (104-end) was expressed by
baculovirus in Sf9 insect cells using an N-terminal GST tag.
MW = 64 kDa. |
|
Description |
PDE7A is a member of the phosphodiesterase family of
proteins that play a critical role in regulating
intracellular levels of cAMP and cGMP. PDE7A is a
high-affinity cAMP-specific PDE and is expressed in T cell
lines, peripheral blood T lymphocytes, epithelial cell
lines, airway and vascular smooth muscle cells, lung
fibroblasts, and eosinophils. PDE7 plays a critical role in
the regulation of human T cell function and selective PDE7
inhibitors are being examined to treat immunological and
inflammatory disorders. PDE7A plays an important role in the
regulation of osteoblastic differentiation. PDE7A depletion
by RNAi upregulates expression of several osteogenic genes
and increases mineralization. |
|
Source |
Sf9 insect cells using baculovirus. |
|
Sequence |
104-end. |
|
Applications |
PDE Assay. |
|
Storage And Stability |
Store product at -70℃. For optimal storage, aliquot target
into smaller quantities after centrifugation and store at
recommended temperature. For most favorable performance,
avoid repeated handling and multiple freeze/thaw cycles. |
|
Gene Information
|
Gene Name |
PDE7A phosphodiesterase 7A [ Homo sapiens ] |
|
Synonyms |
PDE7A; phosphodiesterase 7A; HCP1; PDE7; phosphodiesterase
isozyme 7; EC 3.1.4.17; High affinity cAMP-specific
3',5'-cyclic phosphodiesterase 7A; TM22 |
|
GeneID |
5150 |
|
mRNA Refseq |
NM_002603 |
|
Protein Refseq |
NP_002594 |
|
MIM |
171885 |
|
UniProt ID |
Q13946 |
|
Chromosome Location |
8q13 |
|
Pathway |
Progesterone-mediated oocyte maturation; Purine metabolism |
|
Function |
3',5'-cyclic-AMP phosphodiesterase activity; hydrolase
activity |
|
PDB rendering based on 1zkl.
|
Download Datasheet:
|
|
