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Cat. No. |
Abl1-232M |
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Product
Overview |
Recombinant mouse ABL1 (27-end) was
expressed by baculovirus in Sf9 insect cells using an N-terminal
His tag. MW=135 kDa. |
|
Description |
ABL1 protooncogene encodes a
cytoplasmic and nuclear protein tyrosine kinase that has been
implicated in processes of cell differentiation, cell division,
cell adhesion, and stress response. Activity of ABL protein is
negatively regulated by its SH3 domain and deletion of the SH3
domain turns ABL1 into an oncogene. Translocation and
head-to-tail fusion of the BCR and ABL1 genes is present in many
cases of chronic myelogeneous leukemia. The DNA-binding activity
of the ubiquitously expressed ABL1 tyrosine kinase is regulated
by CDK1-mediated phosphorylation, suggesting a cell cycle
function for ABL1. |
|
Source |
Sf9 insect cells. |
|
Applications |
Kinase Assay, Western Blot. |
|
Stability |
Store product at –70oC. For optimal
storage, aliquot target into smaller quantities after
centrifugation and store at recommended temperature. For most
favorable performance, avoid repeated handling and multiple
freeze/thaw cycles. |
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Gene
Information
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Gene Name |
Abl1 c-abl oncogene 1, receptor tyrosine kinase [ Mus musculus ] |
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Synonyms
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Abl1; c-abl
oncogene 1, receptor tyrosine kinase; Abl; c-Abl; AI325092;
MGC117749; E430008G22Rik |
|
GeneID |
11350 |
|
mRNA Refseq |
NM_001112703 |
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Protein Refseq |
NP_001106174 |
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UniProt ID |
P00520 |
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Chromosome
Location |
2 21.0 cM |
|
Pathway |
Axon guidance;
Cell cycle; Chronic myeloid leukemia; ErbB signaling pathway;
Neurotrophin signaling pathway; Pathways in cancer |
|
Function |
ATP binding;
magnesium ion binding; non-membrane spanning protein tyrosine
kinase activity; nucleotide binding; protein domain specific
binding; protein kinase activity; protein tyrosine kinase
activity; transferase activity |
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PDB rendering based on 1ab2.
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Download Datasheet:
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Abbr.: 
