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Abbr.: ACVRL1(Human)
Source: Mammalian Cells |
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 Kinase >>
ACVRL1, GST-tagged, Active(Human) |
Recombinant Human Activin A Receptor Type II-like 1, GST-tagged, Active [
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Price Inquiry |
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Cat. No. |
ACVRL1-238H |
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Product
Overview |
Recombinant human ALK1 (144-end)
was expressed by baculovirus in Sf9 insect cells using an
N-terminal GST tag. MW=64 kDa. |
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Description |
ALK1 is a serine/threonine-protein
kinase receptor R3 precursor that mediates signal by TGFβ
superfamily. ALK1 functions as a TGFβ type I receptor in
endothelial cells and is responsible for human hereditary
hemorrhagic telangiectasia (HHT) type II. Distinct Smad proteins
(i.e., Smad2/Smad3 and Smad1/Smad5) show interaction with ALK1
and mediate TGFβ signaling. Northern blot and RT-PCR analysis
show that ALK1 specifically induces expression of Smad6, Smad7,
Id1, Id2, endoglin, STAT1, and interleukin 1 receptor in
endothelial cells. ALK1 expression in inflammatory
myofibroblastic tumor of the urinary bladder have also has been
reported. |
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Source |
Sf9 insect cells using baculovirus. |
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Sequence |
144-end. |
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Applications |
Kinase Assay, Western Blot. |
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Stability |
Store product at –70oC. For optimal
storage, aliquot target into smaller quantities after
centrifugation and store at recommended temperature. For most
favorable performance, avoid repeated handling and multiple
freeze/thaw cycles. |
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Gene
Information
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Gene Name |
ACVRL1 activin A receptor type II-like 1 [ Homo sapiens ] |
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Synonyms
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ACVRL1; activin
A receptor type II-like 1; HHT; ALK1; HHT2; ORW2; SKR3; ALK-1;
TSR-I; ACVRLK1; activin A receptor type II-like 1; TGF-B
superfamily receptor type I; activin A receptor, type II-like
kinase 1; serine/threonine-protein kinase receptor R3; EC
2.7.11.30 |
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GeneID |
94 |
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mRNA Refseq |
NM_000020 |
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Protein Refseq |
NP_000011 |
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MIM |
601284 |
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UniProt ID |
P37023 |
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Chromosome
Location |
12q11-q14 |
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Pathway |
Cytokine-cytokine receptor interaction; TGF-beta signaling
pathway |
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Function |
ATP binding;
SMAD binding; activin receptor activity, type I; magnesium ion
binding; nucleotide binding; receptor activity; transferase
activity; transforming growth factor beta binding |
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