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Cat. No. |
DAPK2-290H |
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Product
Overview |
Recombinant human full-length DAPK2
was expressed by baculovirus in Sf9 insect cells using a
N-terminal GST tag. MW=
67kDa. |
|
Description |
DAPK2 or
death-associated protein kinase 2 belongs to a family of
proapoptotic Ca /calmodulin-regulated serine/threonine kinases.
Overexpression of DAPK2 induces cell apoptosis. DAPK2 has been
shown to be a novel Sp1-dependent target gene for E2F1 and
Krüppel-like factor 6 (KLF6) in cell death response. Both E2F1
and KLF6 strongly activate the DAPK2 promoter. DAPK2 plays a
role in granulopoiesis where it is highly expressed. β-catenin
can block anoikis of malignant kidney and intestinal epithelial
cells and promote their anchorage-independent growth by
down-regulating DAPK2. β-catenin-induced down-regulation of
DAPK2 requires the presence of the transcription factor TCF-4. |
|
Source |
Sf9 insect cells
using
baculovirus. |
|
Sequence |
Full-length. |
|
Applications |
Kinase Assay,
Western Blot. |
|
Storage And
Stability |
Store product
at –70oC. For optimal storage, aliquot target into smaller
quantities after centrifugation and store at recommended
temperature. For most favorable performance, avoid repeated
handling and multiple freeze/thaw cycles. |
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Gene
Information
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Gene Name |
DAPK2 death-associated protein kinase 2 [ Homo sapiens ] |
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Synonyms
|
DAPK2;
death-associated protein kinase 2; DRP1; DRP-1; MGC119312; DAP
kinase 2; OTTHUMP00000163874; DAP-kinase-related protein 1; EC
2.7.11.1 |
|
GeneID |
23604 |
|
mRNA Refseq |
NM_014326 |
|
Protein Refseq |
NP_055141 |
|
UniProt ID |
Q9UIK4 |
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Chromosome
Location |
15q22.31 |
|
Pathway |
Bladder cancer;
Pathways in cancer |
|
Function |
ATP binding;
calmodulin binding; nucleotide binding ; protein
serine/threonine kinase activity transferase activity |
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PDB rendering based on 1wmk.
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Download Datasheet:
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