Recombinant Human Janus Kinase 2, GST-tagged, Active   [ Back  ]                         Price Inquiry

Cat. No.

JAK2-336H

Product Overview

Recombinant human JAK2 (804-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag. MW = 42 kDa.

Description

JAK2 is a member of intracellular non-receptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway. JAK2 has two near-identical phosphate-transferring domains. One domain exhibits the kinase activity while the other stabilizes the JAK conformational structure. JAK2 is the predominant JAK kinase activated in response to several growth factors and cytokines such as IL-3, GM-CSF and erythropoietin. JAK2 has been found to be constitutively associated with the prolactin receptor and is required for responses to gamma interferon.

Source

Sf9 insect cells using baculovirus.

Sequence

804-end.

Applications

Kinase Assay, Western Blot.

Storage And Stability

Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

Gene Name

JAK2 Janus kinase 2 [ Homo sapiens ]

Synonyms

JAK2; Janus kinase 2; JTK10; tyrosine-protein kinase JAK2; Janus kinase 2 (a protein tyrosine kinase); EC 2.7.10.2; JAK-2; OTTHUMP00000021024; OTTHUMP00000043260

GeneID

3717

mRNA Refseq

NM_004972

Protein Refseq

NP_004963

MIM

147796

UniProt ID

O60674

Chromosome Location

9p24

Pathway

Adipocytokine signaling pathway; Chemokine signaling pathway; Jak-STAT signaling pathway

Function

ATP binding; Janus kinase activity; SH2 domain binding; acetylcholine receptor binding; growth hormone receptor binding; insulin receptor substrate binding; interleukin-12 receptor binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; peptide hormone receptor binding; phosphoinositide 3-kinase binding; transferase activity