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Cat. No. |
EEF2K-296H |
|
Product
Overview |
Recombinant full-length human EEF2K
was expressed by baculovirus in Sf9 insect cells using an
N-terminal GST tag. MW=125 kDa. |
|
Description |
EEF2K is a highly conserved
calmodulin-dependent protein kinase that links activation of
cell surface receptors to cell division. EEF2K is involved in
the regulation of protein synthesis. It phosphorylates
eukaryotic elongation factor 2 (EEF2), an abundant cytoplasmic
protein that catalyzes the movement of the ribosome along mRNA
during translation in eukaryotic cells, and inhibits the EEF2
function. EEF2K is highly expressed in heart and skeletal
muscle, suggesting that EEF2 phosphorylation may be particularly
important in muscle. EEF2K is highly expressed in patients with
systemic lupus erythematosus as well as in many cancers. |
|
Source |
Sf9 insect cells
using
baculovirus. |
|
Sequence |
Full-length. |
|
Applications |
Kinase Assay,
Western Blot. |
|
Storage And
Stability |
Store product
at –70oC. For optimal storage, aliquot target into smaller
quantities after centrifugation and store at recommended
temperature. For most favorable performance, avoid repeated
handling and multiple freeze/thaw cycles. |
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Gene
Information
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Gene Name |
EEF2K eukaryotic elongation factor-2 kinase [ Homo sapiens ] |
|
Synonyms
|
EEF2K;
eukaryotic elongation factor-2 kinase; eEF-2K; HSU93850;
MGC45041; elongation factor-2 kinase; eEF-2 kinase; calmodulin-dependent
protein kinase III; calcium/calmodulin-dependent eukaryotic
elongation factor-2 kinase; EC 2.7.11.20 |
|
GeneID |
29904 |
|
mRNA Refseq |
NM_013302 |
|
Protein Refseq |
NP_037434 |
|
MIM |
606968 |
|
UniProt ID |
O00418 |
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Chromosome
Location |
16p12 |
|
Pathway |
Signaling by
Insulin receptor |
|
Function |
ATP binding;
calcium ion binding; elongation factor-2 kinase activity;
nucleotide binding; protein serine/threonine kinase activity;
transferase activity; translation factor activity, nucleic acid
binding |
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PDB rendering based on 1wt6.
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Download Datasheet:
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