|
Cat. No. |
Bax-1381M |
|
Product
Overview |
Recombinant
Mouse Bax amino acid 1-171 produced in E.Coli is a single, non-glycosylated
polypeptide chain. The Mouse Bax is purified by proprietary
chromatographic techniques. |
|
Description |
Bcl-2–associated X protein (Bax) belongs to the Bcl-2 protein
family. Bax is a pro-apoptotic Bcl-2 protein containing BH1, BH2
and BH3 domains. Bax accelerates programmed cell death by
binding to, and antagonizing the apoptosis repressor bcl2 or its
adenovirus homolog e1b 19k protein. Bax induces the release of
cytochrome c, activation of casp3, and thereby apoptosis. Bax is
expressed in a wide variety of tissues, with highest levels in
the testis and ovary. Tumor suppressor protein p53 upregulates
the expression of BAX. Bax has been shown to be involved in
p53-mediated apoptosis. |
|
Source |
Escherichia
Coli. |
|
Physical
Appearance |
Sterile
Filtered colorless solution. |
|
Formulation |
The protein
contains 10mM Tris-HCL pH-8, 1mM EDTA and 250mM NaCl. |
|
Applications |
Input marker or
positive control (Western Blotting). |
|
Purity |
Greater than
95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by
SDS-PAGE. |
|
Stability |
Mouse Bax although stable at 12°C
for 1 week, should be stored desiccated below -18°C.
Please prevent
freeze-thaw cycles. |
|
Gene
Information
|
Gene Name |
Bax BCL2-associated X protein [ Mus musculus ] |
|
Synonyms
|
Bax;
BCL2-associated X protein |
|
GeneID |
12028 |
|
mRNA Refseq |
NM_007527 |
|
Protein Refseq |
NP_031553 |
|
UniProt ID |
Q07813 |
|
Chromosome
Location |
7 B5; 7 23.0 cM
|
|
Pathway |
Amyotrophic
lateral sclerosis (ALS); Apoptosis; Colorectal cancer;
Huntington's disease; Huntington's disease; Neurotrophin
signaling pathway; Pathways in cancer; p53 signaling pathway;
Prion diseases |
|
Function |
BH3 domain
binding; protein binding; protein heterodimerization activity |
|
Based on PDB id 1F16.
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Download Datasheet:
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Abbr.: 
