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Cat. No. |
GADD45B-1370H
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Product
Overview |
Recombinant
Human GADD45B produced in E.Coli is a single, non-glycosylated
polypeptide chain containing 160 amino acids and having a
molecular mass of 17.8 kDa. |
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Description |
GADD45B is part
of the nuclear proteins to interact with various proteins whose
transcript levels are raised after stressful growth arrest
conditions and treatment with DNA-damaging agents. GADD45B
reacts to environmental stresses by mediating activation of the
p38/JNK pathway which is mediated through their protein binding
and activating MTK1/MEKK4 kinase, which is an upstream activator
of both p38 and JNK MAPKs. GADD45B is involved in the regulation
of growth and apoptosis. GADD45b takes part during chondrocyte
terminal differentiation and mediates MMP-13 gene expression.
GADD45 in B cells is induced by CD40 via a mechanism that
involves NF-kappa B and that induction suppresses Fas-mediated
killing. GADD45b is down-regulated in most cases of
hepatocellular carcinoma (HCC), and is a molecular marker in the
diagnosis of HCC and as a possible therapeutic target. |
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Source |
Escherichia
Coli. |
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Physical
Appearance |
Sterile
Filtered colorless solution. |
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Purity |
Greater than
95.0% as determined by SDS-PAGE. |
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Amino Acid
Sequence |
MTLEELVACD
NAAQKMQTVT AAVEELLVAA QRQDRLTVGV YESAKLMNVD PDSVVLCLLA
IDEEEEDDIA LQIHFTLIQS FCCDNDINIV RVSGMQRLAQ LLGEPAETQG
TTEARDLHCL LVTNPHTDAW KSHGLVEVAS YCEESRGNNQ WVPYISLQER. |
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Formulation |
The GADD45B
protein solution contains 20mM Tris-HCl pH-7.5 and 20% glycerol. |
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Stability |
GADD45beta
although stable 4°C for 4 weeks, should be stored desiccated
below -18°C. For long term storage it is recommended to add a
carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw
cycles. |
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Gene
Information
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Gene Name |
GADD45B growth arrest and DNA-damage-inducible, beta [ Homo
sapiens ] |
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Synonyms
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growth arrest
and DNA-damage-inducible, beta; MYD118; GADD45BETA;
DKFZp566B133; GADD45B; myeloid differentiation primary response
; DKFZP566B133 ; Myeloid differentiation primary response
protein MyD118; Negative growth regulatory protein MyD118
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GeneID |
4616 |
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mRNA Refseq |
NM_015675 |
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Protein Refseq |
NP_056490 |
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MIM |
604948 |
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UniProt ID |
O75293 |
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Chromosome
Location |
19p13.3 |
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Pathways |
Cell cycle;
MAPK signaling pathway; p53 signaling pathway |
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Function |
protein binding |
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Download Datasheet:
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