|
Cat. No. |
NCOA1-1163H |
|
Description |
Steroid
receptor coactivator 1 (SRC1) is a transcriptional coactivoator
that mediates the activating functions of many of the nuclear
hormone receptors. It is also known as NCoA1 and is
a member of the SRC/p160 coactivator family. SRC1 is a 160 kDa
protein that contains several LXXLL motifs, which are involved
in nuclear receptor interaction.
The region 627-786 contains 3 LXXLL motifs that are involved in
interaction with nuclear hormone receptors nd has been
previously used in assays detecting liganddependent
receptor-cofactor interactions. |
|
Source |
E. coli. |
|
Form |
Liquid.
Supplied in 20 mM Tris-HCl pH 8.0, 20% glycerol, 100 mM KCl, 0.2
mM EDTA and 1 mM DTT. |
|
Purity |
> 95% by SDS-PAGE. |
|
Activity |
100 ng are
sufficient for a protein-protein interaction assay. |
|
Application |
Use only for
research and not for diagnostic purposes. Recombinant GST-SCR1
(627-786) can be used for protein-protein interaction assays. |
|
Usage |
For in vitro
use only. |
|
Storage |
Quality
guaranteed for 12 months store at -80°C. Avoid freeze / thaw
cycles. |
|
Gene
Information
|
Gene Name |
NCOA1 nuclear
receptor coactivator 1 [ Homo sapiens ] |
|
Synonyms
|
NCOA1; nuclear
receptor coactivator 1; SRC1; KAT13A; RIP160; F-SRC-1; bHLHe42;
bHLHe74; MGC129719; MGC129720; Hin-2 protein;
OTTHUMP00000155181; OTTHUMP00000155182; PAX3/NCOA1 fusion
protein; steroid receptor coactivator-1; EC 2.3.1.48;
OTTHUMP00000155183; NCoA-1; RIP160; SRC-1; Protein Hin-2; Renal
carcinoma antigen NY-REN-52; Steroid receptor coactivator 1;
nuclear receptor coactivator 1 |
|
GeneID |
8648 |
|
mRNA Refseq |
NM_003743 |
|
Protein Refseq |
NP_003734 |
|
MIM |
602691 |
|
UniProt ID |
Q15788 |
|
Chromosome
Location |
2p23 |
|
Function |
DNA binding;
acyltransferase activity; androgen receptor binding; chromatin
binding; histone acetyltransferase activity; nuclear hormone
receptor binding; protein N-terminus binding; signal transducer
activity; transcription coactivator activity; transcription
regulator activity; transferase activity |
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PDB rendering based on 1oj5.
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Download Datasheet:
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Abbr.: 
