|
Cat. No. |
AGER -917H |
|
Product Overview |
Recombinant Human sRAGE
encoding the mature Human sRAGE (Ala23-AlaP342) with 6 His
tag on the N-Terminus was expressed in E. Coli. This protein
was purified by Ni-NTA column.
MW = 39.0 KD. |
|
Description |
RAGE, the receptor for advanced glycation endproducts is a
transmembrane receptor of the immunoglobulin super family
which was first characterized in 1992 by Neeper et al. Its
name comes from its ability to bind advanced glycation
endproducts (AGE), a heterogeneous group of non-enzymatically
altered proteins. Besides AGEs, RAGE is also able to bind
other ligands and is thus often referred to as a pattern
recognition receptor. |
|
Source |
Escherichia Coli. |
|
Amino Acid Sequence |
Human sRAGE (Ala23-AlaP342). 23AQNITARI GEPLVLKCKG
APKKPPQRLE WKLNTGRTEAWKVLSPQGGG PWDSVARVLP NGSLFLPAVG
IQDEGIFRCQ AMNRNGKETK SNYRVRVYQI PGKPEIVDSA SELTAGVPNK
VGTCVSEGSY PAGTLSWHLD GKPLVPNEKG VSVKEQTRRHPETGLFTLQS
ELMVTPARGG DPRPTFSCSF SPGLPRHRAL RTAPIQPRVW EPVPLEEVQL
VVEPEGGAVA PGGTVTLTCE VPAQPSPQIH WMKDGVPLPL PPSPVLILPE
IGPQDQGTYS CVATHSSHGP QESRAVSISI IEPGEEGPTA GSVGGSGLGTLA
342. |
|
Application |
Cell biology. |
|
Purity |
>95% in SDS gel. |
|
Formulation |
Lyophilized 50 μg Human sRAGE in 50 μl of TBS ( 20 mM Tris,
50mM NaCl,pH8.0 ). Carry free. |
|
Reconstitution |
Add 500 μl deionized water to the vial to prepare a working
stock solution at 200 μg/mL . Allow to set at least 30
minutes at 4° C, mix well. |
|
Storage |
Store lyophilized protein at -20 °C or -70 °C. Lyophilized
protein is stable for up to 6 months from date of receipt at
- 20 °C to -70 °C. Upon reconstitution, this protein can be
stored at -20 °C for a few weeks or at -70 °C in a manual
defrost freezer for long term storage (six months). Aliquot
reconstituted protein to avoid repeated freezing / thawing
cycles. |
|
Gene Information
|
Gene Name |
AGER advanced glycosylation end product-specific receptor [
Homo sapiens ] |
|
Synonyms |
AGER; advanced glycosylation end product-specific receptor;
RAGE; MGC22357; receptor for advanced glycosylation
end-products; Receptor for advanced glycosylation end
products; MGC22357; OTTHUMP00000029155; OTTHUMP00000029156;
advanced glycosylation end product-specific receptor |
|
GeneID |
177 |
|
mRNA Refseq |
NM_001136 |
|
Protein Refseq |
NP_001127 |
|
MIM |
600214 |
|
UniProt ID |
Q15109 |
|
Chromosome Location |
6p21.3 |
|
Function |
advanced glycation end-product receptor activity; protein
binding; transmembrane receptor activity |
|
|
Download Datasheet:
|
|
Abbr.: 
