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Cat. No. |
BCL10-1016H |
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Description |
Bcl-10 is an
intracellular signaling protein identified from the t (p22;q32)
breakpoint in MALT lymphomas. The human Bcl-10 gene encodes a
protein of 233 amino acids containing an N-terminal Caspase
Recruitment Domain (CARD) that mediates self-oligomerization and
the Cterminal region of Bcl-10. Bcl-10 is expressed ubiquitously
with highexpression levels in lymphoid tissues and in the
developing central nerve system. Mutations have been found in
cases of follicular lymphoma and diffuse large B cell lymphoma.
Bcl-10 is a positive regulator of antigenreceptor induced NF-B
activation and Bcl-10-initiated activation of NF-B can be
inhibited by cotransfection of dominant-negative mutants of
TRAF2, NIK, IKKa or IkBa. The wild type human Bcl-10 protein was
expressed in baculovirus system and purified by an affinity
column in combination with FPLC chromatography. Purified protein
is greater than 95% homogeneous and contains no detectable
proteases, DNase, and RNase activity. |
|
Source |
Sf9 insect
cells. |
|
Form |
Liquid.
Supplied in 20 mM Tris-HCl pH 8.0, 100 mM KCl, 0.2 mM EDTA, 1 mM
DTT and 20% glycerol. |
|
Purity |
> 95% by SDS-PAGE. |
|
Activity |
100 ng are
required for a protein-protein interaction assay. |
|
Application |
Recombinant
Bcl-10 protein can be used for 1) protein-protein interaction
assay 2) for in vitro transcription assay 3) for cell growth
assay. |
|
Usage |
For in vitro
use only. |
|
Storage |
Quality
guaranteed for 12 months store at -80°C Avoid freeze / thaw
cycles |
|
Gene
Information
|
Gene Name |
BCL10 B-cell CLL/lymphoma 10 [ Homo sapiens ] |
|
Synonyms
|
BCL10; B-cell
CLL/lymphoma 10; CLAP; mE10; CIPER; c-E10; CARMEN;
OTTHUMP00000011647; OTTHUMP00000036080; CARD-containing
proapoptotic protein; CARD containing molecule enhancing NF-kB;
CARD-containing apoptotic signaling protein; caspase-recruiting
domain-containing protein; CARD-like apoptotic protein;
Bcl-10; B-cell CLL/lymphoma 10;
hCLAP; Cellular-E10; mE10; Mammalian CARD-containing adapter
molecule E10; cCARMEN; Cellular homolog of vCARMEN; Cellular
homolog of vCARMEN |
|
GeneID |
8915 |
|
mRNA Refseq |
NM_003921 |
|
Protein Refseq |
NP_003912 |
|
MIM |
603517 |
|
UniProt ID |
O95999 |
|
Chromosome
Location |
1p22 |
|
Pathway |
B cell receptor
signaling pathway; T cell receptor signaling pathway |
|
Function |
NF-kappaB
binding; kinase activator activity; protein C-terminus binding;
protein kinase B binding; protein self-association;
transcription coactivator activity; ubiquitin binding; ubiquitin
protein ligase binding |
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Abbr.: 
