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Cat. No. |
OPCML-819H |
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Product
Overview |
Recombinant human
OPCML was produced in HEK293. A DNA sequence encoding the human OPCML precursor (NP_002536.1) ( Met 1- Asn 322 ) was expressed
with a C-terminal his tag. |
|
Description |
Opioid-binding
Cell Adhesion Molecule (OBCAM), also known as OPCML, is a
GPI-anchored cell adhesion molecule in the plasma membrane, and
contains three C2 type immunoglobulin (Ig)-like domains. OPCML
also belongs to the IgLON subfamily in the Ig superfamily
consisting of three members, LAMP, OBCAM, and Neurotrimin. These
molecules interact homophilically and heterophilically within
the family, and OBCAM acts only as heterodimers with LAMP or
Neurotrimin and possibly inhibits neurite outgrowth from
cerebellar granule cells. OPCML is originally identified as a
neuron-specific molecule mainly expressed in cerebral cortex and
hippocampus, and available evidences have suggested that it may
be involved in neuronal plasticity, as well as the establishment
and remodeling of neural circuits. Furthermore, the OPCML
protein defects may play an important role in the carcinogenesis
of cervical or ovarian cancers, and this gene is regarded as a
candidate TSG (tumor suppressor gene). |
|
Molecular Mass |
The mature
recombinant human OPCML consists of 306 amino acids and has a
calculated molecular mass of 34 KDa. As a result of
glycosylation, rhOPCML migrates as an approximately 55-60 KDa
protein in SDS-PAGE under reducing conditions. |
|
Source |
Human
Cells(HEK293). |
|
Predicted
N-terminal |
Gly 28. |
|
Endotoxin |
< 1.0 EU per
1μg cytokine as determined by the LAL method. |
|
Formulation |
Supplied as a
0.2μm filtered solution of PBS, pH7.4. |
|
Reconstitution |
Follow the
instructions on the vial. Centrifuge the vial at 4℃ before
opening to recover the entire contents. |
|
Purity |
> 95%, as
determined by SDS-PAGE. |
|
Stability |
Samples are
stable for up to twelve months from date of receipt -70℃. |
|
Storage |
Store it under
sterile conditions at -70℃. It is recommended that the protein
be aliquoted for optimal storage and be used as soon as
possible. Avoid repeated freeze-thaw cycles. |
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Gene
Information
|
Gene Name |
OPCML opioid binding protein/cell adhesion molecule-like [ Homo
sapiens ] |
|
Synonyms
|
OPCML; opioid
binding protein/cell adhesion molecule-like; OPCM; OBCAM;
IGLON1; IgLON family member 1; opiate binding-cell adhesion
molecule; opioid binding protein/cell adhesion molecule-like
preprotein; Opioid-binding cell adhesion molecule; opioid
binding protein/cell adhesion molecule-like preprotein |
|
GeneID |
4978 |
|
mRNA Refseq |
NM_001012393 |
|
Protein Refseq |
NP_001012393 |
|
MIM |
600632 |
|
UniProt ID |
Q14982 |
|
Chromosome
Location |
11q25 |
|
Function |
opioid receptor
activity; protein binding |
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Download Datasheet:
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