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Description
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Metallothionein (MT) is a family of cysteine-rich, low molecular weight (MW ranging from 3500 to 14000 Da) proteins. MTs have the capacity to bind both physiological (Zn, Cu, Se,...) and xenobiotic (Cd, Hg, Ag,...) heavy metals through the thiol group of its cysteine residues, which represents nearly the 30% of its amino acidic residues. MT was discovered in 1957 by Vallee and Margoshe from purification of a Cd-binding protein from horse (equine) renal cortex. MTs function is not clear, but experimental data suggest MTs may provide protection against metal toxicity, be involved in regulation of physiological metals (Zn and Cu) and provide protection against oxidative stress. There are four main isoforms expressed in humans. In the human body, large quantities are synthesised primarily in the liver and kidneys. Their production is dependent on availability of the dietary minerals, as zinc, copper and selenium, and the amino acids histidine and cysteine. Biomart native rabbit metallothionein Contains both form I and form II MT Zinc content greater than 6%
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