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Cat. No. |
ACP5-240H
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Product
Overview |
Recombinant Human
acid
phosphatase 5, tartrate resistant
encoding the human ACP5 (NP_001602.1) precursor (Met 1-Pro
320) was expressed with a C-terminal his tag. It was
produced in Human Cells (HEK293). |
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Description |
ACP5, also
termed as tartrate-resistant acid phosphatase (TRAP), is the
most cationic isozyme of acid phosphatase. Widespread
expression of TRAP was detected in various human tissues,
and exists at high levels by osteoclasts, macrophages and
dendritic cells. ACP5 plays a role in many biological
processes including skeletal development, collagen synthesis
and degradation, the mineralisation of bone, cytokine
production by macrophages and dendritic cells, macrophage
recruitment, dendritic cell maturation, and invloved in the
development of Th1 responses as well.
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Molecular
Mass |
The
secreted recombinant human ACP5 comprises 310 amino acids
with a predicted molecular mass of 35 kDa as estimated by
SDS-PAGE under reducing conditions. |
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Source |
Human Cells
(HEK293). |
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Predicted N
Terminal |
Ala 22. |
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Purity |
> 95%, as
determined by SDS-PAGE. |
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Formulation |
Supplied as
a 0.2μm filtered solution of PBS, pH7.4. |
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Stability |
Samples are stable for up to
twelve months from date of receipt -70℃. |
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Endotoxin |
< 1.0 EU
per 1μg cytokine as determined by the LAL method. |
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Reconstitution |
Follow the instructions on the
vial. Centrifuge the vial at 4℃
before opening to recover the entire contents. |
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Storage |
Store it under sterile
conditions at -70℃.
It is recommended that the protein be aliquoted for optimal
storage and be used as soon as possible. Avoid repeated
freeze-thaw cycles. |
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Gene
Information
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Gene Name |
ACP5 acid phosphatase 5, tartrate resistant [ Homo sapiens ] |
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Synonyms
|
ACP5; acid
phosphatase 5, tartrate resistant; TRAP; MGC117378;
TrATPase; tartrate-resistant acid ATPase; tartrate resistant
acid phosphatase 5; EC 3.1.3.2 |
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GeneID |
54 |
|
mRNA Refseq |
NM_001111034 |
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Protein
Refseq |
NP_001104504 |
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MIM |
171640 |
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UniProt ID |
P13686 |
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Chromosome
Location |
19p13.3-p13.2 |
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Pathway |
Lysosome;
Riboflavin metabolism; gamma-Hexachlorocyclohexane
degradation; Metabolism of vitamins and cofactors |
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Function |
acid
phosphatase activity; hydrolase activity; iron ion binding;
metal ion binding |
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PDB rendering based on 1war.
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Download Datasheet:
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