Recombinant Human Bone Morphogenetic Protein 4, liquid   [ Back  ]                         Price Inquiry

Cat. No.

BMP4-14H

Product Overview

Recombinant BMP-4 was expressed as insoluble protein aggregate in E.coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer. MW = 13.2 kDa (117 aa).

Description

Bone morphogenetic protein 4 (BMP-4) is a member of the bone morphogenetic protein family which belongs to the TGF-β superfamily. This protein is a vital regulatory molecule that functions throughout bone and cartilage development, specifically tooth development, limb formation, bone induction, and fracture repair. In human embryonic development, BMP- 4 is required for the early differentiation of the embryo and establishing of a dorsal-ventral axis. And it is overexpressed in patients with fibrodysplasia ossificans progressiva.

Source

E.coli.

Amino Acid Sequence

MSPKHHSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLA

DHLNS TNHAIVQTLV NSVNSSIPKA CCVPTELSAISMLYLDEYDKVVLKNYQEMV VE

GCGCR.

Form

Liquid. In 10mM Sodium citrate buffer (pH 3.5), 10% glycerol.

Purity

> 95% by SDS – PAGE.

Concentration

0.5 mg/ml (determined by Bradford assay).

Endotoxin Level

< 1.0 EU per 1 μg of protein (determined by LAL method).

Storage

Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

Gene Name

BMP4 bone morphogenetic protein 4 [ Homo sapiens ]

Synonyms

ZYME; BMP2B; BMP2B1; DVR4; MCOPS6; BMP-2B; BMP-4; Bone morphogenetic protein 4 precursor; bone morphogenetic protein 2B; bone morphogenetic protein 4; BMP4

GeneID

652

mRNA Refseq

NM_001202

Protein Refseq

NP_001193

MIM

112262

UniProt ID

P12644

Chromosome Location

q22-q23

Function

cytokine activity. growth factor activity. heparin binding. protein binding. signal transducer activity