Mouse anti-Trim5α Monoclonal Antibody   [ Back  ]                         Price Inquiry

Cat. No.

CAB291

Description

TRIM5-alpha is a protein that is found in the cells of many mammals and fends of various retrovirus infections. It protects monkeys from infection with HIV-1, and humans from infection with some other viruses. If a retrovirus has entered a cell, it needs to shed its capsid in order to reversely transcribe its genes, so that they can be expressed by the host cell. It is believed that TRIM5 alpha, which is present in the cytoplasm, somehow recognizes the capsid and blocks its shedding, thereby stopping the virus in its tracks. It thus represents an intracellular defense completely separate from the rest of the body's immune system.

Synonyms

EC 6.3.2.-; OTTHUMP00000069811; OTTHUMP00000069812; RNF88; TRIM5alpha; TRIM5-alpha; RING finger protein 88; tripartite motif protein TRIM; tripartite motif protein TRIM5; tripartite motif-containing 5; tripartite motif-containing protein 5 alpha

Species

Human

Isotype

IgG1

Immunogen

Ni-NTA purified truncated recombinant human trim5 alpha expressed in E. Coli strain BL21 (DE3).

Application

Western Blot, IHC; Western Blot: Dilution 1: 1,000- 1: 5,000; IHC(P): Dilution 1: 100- 1: 400; IHC(F): Dilution 1: 200- 1: 400; Determining optimal working dilutions by titration test.

Formulation

Crude Asites.

Storage

-20℃