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Cat. No. |
VAMP4-484H |
|
Product
Overview |
Recombinant
human VAMP4 protein, fused to His-tag at C-terminus, was
expressed in E.coli and purified by using conventional
chromatography. MW = 14.5 kDa (123aa). |
|
Description |
VAMP4, also
known as vesicle-associated membrane protein 4, is a member of
the synaptobrevin family involved in docking and/or fusion of
vesicles with cell membrane. This protein is enriched in the
trans-Golgi network and may play a role in trans-Golgi
network-to-endosome transport. VAMP4 is involved in the pathway
that functions to remove an inhibitor (probably synaptotagmin-4)
of calcium-triggered exocytosis during the maturation of
secretory granules. |
|
Source |
E.coli. |
|
Amino Acid
Sequence |
MPPKFKRHLN
DDDVTGSVKS ERRNLLEDDS DEEEDFFLRG PSGPRFGPRN DKIKHVQNQV
DEVIDVMQEN ITKVIERGER LDELQDKSES LSDNATAFSN RSKQLRRQMW
WRGCKLEHHH HHH. |
|
Form |
Liquid. In 20
mM Tris-HCl buffer (pH 8.0) containing 0.1 M NaCl, and
20% glycerol. |
|
Purity |
> 90% by SDS –
PAGE. |
|
Concentration |
0.5 mg/ml
(determined by Bradford assay). |
|
Endotoxin Level |
< 1.0 EU per 1
μg of protein (determined by LAL method ). |
|
Storage |
Can be stored
at +4°C short term (1-2 weeks). For long term storage, aliquot
and store at -20°C or -70°C. Avoid repeated freezing and thawing
cycles. |
|
Gene
Information
|
Gene Name |
VAMP4 vesicle-associated membrane protein 4 [ Homo sapiens ] |
|
Synonyms
|
VAMP4;
vesicle-associated membrane protein 4; VAMP24;
VAMP-4 |
|
GeneID |
8674 |
|
mRNA Refseq |
NM_003762 |
|
Protein Refseq |
NP_003753 |
|
MIM |
606909 |
|
UniProt ID |
O75379 |
|
Chromosome
Location |
1q24-q25 |
|
Pathway |
SNARE
interactions in vesicular transport |
|
PDB rendering based on 2nps.
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Download Datasheet:
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