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Description |
Interleukin-16,
also known as lymphocyte chemoattractant factor (LCF), is a
chemotactic cytokine that stimulates a migratory response in
CD4+ lymphocytes, monocytes, and eosinophils through binding to
the CD4 receptor . IL-16 induces human T-lymphocyte expression
of interleukin 2 receptor and upregurates major
histocompatibility complex Ⅱmolecules on resting human T
lymphocyte. It is able to render CD4+ T cells unresponsive to
TCR/CD3 stimuli. Moreover, IL-16 inhibits the replication of T
cell and monocyte tropic HIV strains in vitro. |
