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Description |
IKBKB
(Inhibitor of kappa light polypeptide gene enhancer in B-cells,
kinase beta, also called IKK2/IKKB), is a member of the IKK
complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and
IKAP. Phosphorylation of I-Kappa-B on a serine residue by the
IKK complex frees NF-kB from I-Kappa-B and marks it for
degradation via ubiquination. IKK-beta has been shown to
activate NF-kB and phosphorylate IKB-alpha and beta.
Phosphorylation of 2 sites at the activation loop of IKK-beta is
essential for activation of IKK by TNF and IL1. Once activated,
IKK-beta autophosphorylates which in turn decreases IKK activity
and prevents prolonged activation of the inflammatory response.
Additionally, IKK-beta activity can also be regulated by MEKK-1. |
