|
Cat. No. |
BAD-82H |
|
Product
Overview |
Recombinant
Human Bcl2 antagonist of cell death (BAD) full length protein
expressed in E.coli. |
|
Description |
The Bcl-2
family of protein is characterized by its ability to modulate
cell death under a broad range of physiologic conditions. Bcl-2
and several related proteins function to inhibit apoptosis while
other members of the Bcl-2 family, such as Bax and Bak, enhance
cell death under various conditions. Bad exhibits homology to
Bcl-2 limited to the BH1, but not with Bax, Bcl-xS, Mcl-1, A1 or
itself. In mammalian cells, Bad binds with greater affinity to
Bcl-xL than to Bcl-2 and reverses the death repressor activity
of Bcl-xL but not Bcl-2. |
|
Source |
Escherichia
Coli. |
|
Physical
Appearance |
Sterile
Filtered clear solution. |
|
Formulation |
BAD protein at
100μg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol. |
|
Applications |
• ELISA • Inhibition Assays
• Western
Blotting. |
|
Characterization |
On SDS-PAGE
commassie blue stained gel, the purified recombinant protein
shows a band at 51kDa. |
|
Storage |
Store vial at
-20℃ to -80℃.
When stored at the recommended temperature, this protein is
stable for 12 months. Please prevent freeze-thaw cycles. |
|
Gene
Information
|
Gene Name |
BAD BCL2-associated agonist of cell death [ Homo sapiens ] |
|
Synonyms
|
BAD;
BCL2-associated agonist of cell death; BBC2; BCL2L8;
Bcl-2-binding component 6;
Bcl-2-like protein 8; Bcl2-L-8; Bcl-XL/Bcl-2- associated death
promoter |
|
GeneID |
572 |
|
mRNA Refseq |
NM_004322 |
|
Protein Refseq |
NP_004313 |
|
UniProt ID |
Q92934 |
|
Chromosome
Location |
11q13.1 |
|
MIM |
603167 |
|
Pathway |
cute myeloid
leukemia; Alzheimer's disease; Amyotrophic lateral sclerosis
(ALS); Apoptosis; Chronic myeloid leukemia; Endometrial cancer;
ErbB signaling pathway; Focal adhesion; Insulin signaling
pathway; Melanoma; Neurotrophin signaling pathway; Non-small
cell lung cancer; Pancreatic cancer; Pancreatic cancer; thways
in cancer; VEGF signaling pathway; Apoptosis |
|
Function |
otein binding;
protein kinase binding |
|
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Download Datasheet:
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Abbr.: 
