|
Cat. No. |
YWHAG-12H |
|
Product
Overview |
Recombinant
Human KCIP-1 produced in E.Coli is a single, non-glycosylated,
polypeptide chain containing 247 amino acids (1-247) and having
a molecular mass of 28 kDa. 14-3-3-gamma is purified by
proprietary chromatographic techniques. |
|
Description |
The 14-3-3
family of proteins plays a key regulatory role in signal
transduction, checkpoint control, apoptotic and nutrient-sensing
pathways. 14-3-3 proteins are highly conserved and ubiquitously
expressed. There are at least seven isoforms, β, γ, ε, σ, ζ, τ
and η that have been identified in mammals. The 14-3-3gamma, a
subtype of the 14-3-3 family of proteins, was thought to be
brain and neuron-specific. It has been shown to interact with
RAF1 and protein kinase C, proteins involved in various signal
transduction pathways. |
|
Source |
Escherichia
Coli. |
|
Amino Acid
Sequence |
MVDREQLVQK
ARLAEQAERY DDMAAAMKNV TELNEPLSNE ERNLLSVAYK NVVGARRSSW
RVISSIEQKT SADGNEKKIE MVRAYREKIE KELEAVCQDV LSLLDNYLIK
NCSETQYESK VFYLKMKGDY YRYLAEVATG EKRATVVESS EKAYSEAHEI
SKEHMQPTHP IRLGLALNYS VFYYEIQNAP EQACHLAKTA FDDAIAELDT
LNEDSYKDST LIMQLLRDNL TLWTSDQQDD DGGEGNN. |
|
Physical
Appearance |
Sterile
filtered colorless solution. |
|
Purity |
Greater than 95.0% as determined by: (a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE. |
|
Formulation |
1 mg/ml
solution containing 20mM Tris 7.5. |
|
Storage |
Recombinant
Human 14-3-3 Gamma although stable at 14℃
for 1 week, should be stored desiccated below -18℃.
Please prevent freeze thaw cycles. |
|
Gene
Information
|
Gene Name |
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
activation protein, gamma polypeptide [ Homo sapiens ] |
|
Synonyms
|
tyrosine
3-monooxygenase/tryptophan 5-monooxygenase activation protein,
gamma polypeptide; 14-3-3GAMMA; YWHAG; 14-3-3 gamma; KCIP-1;
Protein kinase C inhibitor protein 1 |
|
GeneID |
7532 |
|
mRNA Refseq |
NM_012479 |
|
Protein Refseq |
NP_036611 |
|
MIM |
605356 |
|
UniProt ID |
P61981 |
|
Chromosome
Location |
7q11.23 |
|
Pathway |
Cell cycle;
Cell Cycle, Mitotic; Neurotrophin signaling pathway |
|
Function |
insulin-like
growth factor receptor binding; protein kinase C inhibitor
activity; protein domain specific binding; protein kinase C
binding |
|
PDB rendering based on 2b05.
|
Download Datasheet:
|
|
Abbr.: 
