|
Cat. No. |
VEGFA-130H
|
|
Product
Overview |
Recombinant
VEGF121 protein was expressed in E.coli and purified by using
conventional chromatography techniques, 16.3 kDa (142aa). |
|
Description |
Vascular
endothelial growth factor (VEGF) is homodimeric, heparin-binding
glycoprotein involved in both angiogenesis and vasculogenesis.
VEGF is expressed as multiple alternately spliced isoforms of
VEGF121, 165, 189 and 206. VEGF binds to the receptor tyrosine
kinases VEGF R1 (Flt-1) and VEGF R2 (KDR/Flk-1) to activate
signal transduction and regulate both physiological and
pathological angiogenesis. |
|
Sequences of
amino acids |
MGSSHHHHHH
SSGLVPRGSH MAPMAEGGGQ NHHEVVKFMD VYQRSYCHPI ETLVDIFQEY
PDEIEYIFKP SCVPLMRCGG CCNDEGLECV PTEESNITMQ IMRIKPHQGQ
HIGEMSFLQH NKCECRPKKD RARQEKCDKP RR |
|
Formulation |
Liquid in 20mM
Tris pH 8.0 |
|
Purity |
> 95% by SDS -
PAGE |
|
Concentration |
1 mg/ml
(determined by Bradford assay) |
|
Endotoxin Level |
< 1.0 EU per
1ug of protein (determined by LAL method) |
|
Storage |
Can be stored
at +4°C short term (1-2 weeks). For long term storage, aliquot
and store at -20°C or -70°C. Avoid repeated freezing and thawing
cycles. |
|
Gene
Information
|
Gene Name |
VEGFA vascular endothelial growth factor A [ Homo sapiens ]
|
|
Synonyms
|
VEGFA; vascular
endothelial growth factor A; VPF; VEGF; MVCD1; VEGF-A; MGC70609;
vascular permeability factor; vascular endothelial growth factor
isoform VEGF165; Vascular permeability factor; vascular
endothelial growth factor A |
|
GeneID |
7422 |
|
mRNA Refseq |
NM_001025366 |
|
Protein Refseq |
NP_001020537 |
|
MIM |
192240 |
|
UniProt ID |
P15692 |
|
Chromosome
Location |
6p12 |
|
Pathway |
Cytokine-cytokine receptor interaction; Focal adhesion;
Pancreatic cancer; Renal cell carcinoma; VEGF signaling pathway;
mTOR signaling pathway; Hemostasis; Signaling by VEGF |
|
Function |
cell surface binding;
cytokine activity;
extracellular matrix binding;
fibronectin binding;
growth factor activity;
heparin binding;
platelet-derived growth factor
receptor binding;
protein homodimerization activity;
vascular endothelial growth factor
receptor 1 binding;
vascular endothelial growth factor
receptor 2 binding |
|
|
Download Datasheet:
|
|
Abbr.: 
