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Description |
The TUG protein
contains a UBX domain, for GLUT4. In truncated form, TUG acts in
a dominant-negative manner to inhibit insulin-stimulated GLUT4
redistribution in Chinese hamster ovary cells and 3T3-L1
adipocytes. Full-length TUG forms a complex specifically with
GLUT4. In 3T3-L1 adipocytes, this complex is present in
unstimulated cells and is largely disassembled by insulin.
Endogenous TUG is localized with the insulin-mobilizable pool of
GLUT4 in unstimulated 3T3-L1 adipocytes, and is not mobilized to
the plasma membrane by insulin. |
