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Cat. No. |
NAT6-132H
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Product
Overview |
Recombinant
human N-acetyltransferase 6 protein, fused to His-tag at
N-terminus, was expressed in E.coli and purified by using
conventional chromatography, 35.9 kDa (328aa)(Real molecular
weight on SDS-PAGE will be shift up). |
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Description |
N-acetyltransferase,
also known as FUS2 (NAT6), is an enzyme that catalyzes the
transfer of acetyl groups from acetyl-CoA to acrylamines. This
enzyme is physically localized in the cytoplasm and its activity
has been documented by its feasibility to acetylate the
N-terminus of proteins using a ping-pong-like mechanism and by
its substrate specificity. Since the Fus-2 gene maps to the
chromosomal region 3p21.3, which contains at least one tumor
suppressor gene, the N-acetyltransferase functions of Fus-2 may
be relevant to its potential role in cancer. |
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Sequences of
amino acids |
MGSSHHHHHH
SSGLVPRGSH MQELTLSPGP AKLTPTLDPT HRMELILSTS PAELTLDPAC
QPKLPLDSTC QPEMTFNPGP TELTLDPEHQ PEETPAPSLA ELTLEPVHRR
PELLDACADL INDQWPRSRT SRLHSLGQSS DAFPLCLMLL SPHPTLEAAP
VVVGHARLSR VLNQPQSLLV ETVVVARALR GRGFGRRLME GLEVFARARG
FRKLHLTTHD QVHFYTHLGY QLGEPVQGLV FTSRRLPATL LNAFPTAPSP
RPPRKAPNLT AQAAPRGPKG PPLPPPPPLP ECLTISPPVP SGPPSKSLLE
TQYQNVRGRP IFWMEKDI |
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Formulation |
Liquid. In 20
mM Tris-HCl buffer (pH 8.0) containing 100 mM NaCl 20%
glycerol. |
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Purity |
> 95% by SDS -
PAGE |
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Concentration |
0.5 mg/ml
(determined by Bradford assay) |
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Storage |
Can be stored
at +4°C short term (1-2 weeks). For long term storage, aliquot
and store at -20°C or -70°C. Avoid repeated freezing and thawing
cycles. |
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Gene
Information
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Gene Name |
NAT6 N-acetyltransferase 6 (GCN5-related) [ Homo sapiens ] |
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Synonyms
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EC 2.3.1.-; FUS-2; FUS2; N-acetyltransferase
6; N-acetyltransferase 6 (GCN5-related); Protein fus-2; Protein
fusion-2; putative tumor suppressor;
NAT6
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GeneID |
24142 |
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mRNA Refseq |
NM_012191 |
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Protein Refseq |
NP_036323 |
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MIM |
607073 |
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UniProt ID |
Q93015 |
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Chromosome
Location |
3p21.3 |
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Pathway |
1- and
2-Methylnaphthalene degradation; Alkaloid biosynthesis II;
Benzoate degradation via CoA ligation; Ethylbenzene degradation;
Glycerophospholipid metabolism; Limonene and pinene degradation;
Phenylalanine metabolism; Tyrosine metabolism |
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Function |
N-acetyltransferase activity; acyltransferase activity;
transferase activity |
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