|
Cat. No. |
CAB112 |
|
Antigen
information |
Interleukin 8
(IL8) is a member of the CXC chemokine family. This chemokine is
one of the major mediators of the inflammatory response. This
chemokine is secreted by several cell types. It functions as a
chemoattractant, and is also a potent angiogenic factor. IL8 is
believed to play a role in the pathogenesis of bronchiolitis, a
common respiratory tract disease caused by viral infection. IL8
and other ten members of the CXC chemokine gene family form a
chemokine gene cluster in a region mapped to chromosome 4q. |
|
Specificity |
Recognizes
human interleukin 8 protein. |
|
Antibody class |
Mouse IgG1 |
|
Applications |
Can be used in
ELISA and Western blotting. |
|
Presentation
and storage |
Purified
antibody is available at a concentration of 1 mg/ml in
glycine-tris-Hcl buffer pH 7.0, with 0.02% Proclin 300 as a
preservative. The antibody may be stored at -20° C for one year
in its original formulation. Additionally, antibody may be
stored at 2° to 8° C for up to 1 month without detectable loss
of activity. Avoid repeated freeze-thaw cycles of the diluted
antibody. |
|
Gene
Information
|
Gene Name |
IL8 interleukin 8 [ Homo sapiens ] |
|
Synonyms
|
IL8; IL-8; NAF;
GCP1; LECT; LUCT; NAP1; CXCL8; GCP-1; LYNAP; MDNCF; MONAP;
3-10C; AMCF-I; CXCL8; GCP-1; GCP1; K60; NAP-1; NAP1; SCYB8;
TSG-1; b-ENAP; interleukin 8; neutrophil-activating peptide 1;
chemokine (C-X-C motif) ligand 8; beta-thromboglobulin-like
protein; granulocyte chemotactic protein 1; monocyte-derived
neutrophil chemotactic factor; small inducible cytokine
subfamily B, member 8; lymphocyte-derived neutrophil-activating
factor; emoctakin; Emoctakin; C-X-C motif chemokine 8;
Granulocyte chemotactic protein 1; Monocyte-derived neutrophil
chemotactic factor; Monocyte-derived neutrophil-activating
peptide; Neutrophil-activating protein 1; Protein 3-10C; T cell
chemotactic factor; T-cell chemotactic factor |
|
GeneID |
3576 |
|
mRNA Refseq |
NM_000584 |
|
Protein Refseq |
NP_000575 |
|
MIM |
146930 |
|
UniProt ID |
P10145 |
|
Chromosome
Location |
4q13-q21 |
|
Pathways |
Cytokine-cytokine receptor interaction; Epithelial cell
signaling in Helicobacter pylori infection; Leukocyte
transendothelial migration; Toll-like receptor signaling
pathway; Signaling by GPCR |
|
Function |
chemokine
activity; interleukin-8 receptor binding; protein binding |
|
PDB rendering based on 1IL8.
|
Download Datasheet:
|
|
