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Antigen
information |
Myelin basic
protein (MBP) is a protein believed to be important in the
process of myelination of nerves in the central nervous system
(CNS). MBP was initially sequenced in 1979 after isolation from
myelin membranes. Since that time, knockout mice deficient in
MBP have been developed which showed decreased amounts of CNS
myelination and a progressive disorder characterized by tremors,
seizures, and early death. The gene for MBP is on chromosome 18;
the protein localizes to the CNS and to various cells of the
hematopoietic system. The pool of MBP in the central nervous
system is very diverse, with several splice variants being
expressed and a large number of post-translational modifications
on the protein, which include phosphorylation, methylation,
deamidation and citrullination. In melanocytic cell types MBP
gene expression may be regulated by MITF . |
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Presentation
and storage |
Purified
antibody is available at a concentration of 1mg/ml in citrate-tris-NaCl
buffer pH7.0, with 0.02%Proclin 300 as a preservative. The
antibody may be stored at -20° C for one year in its original
formulation. Additionally, antibody may be stored at 2° to 8° C
for up to 1 month without detectable loss of activity. Avoid
repeated freeze-thaw cycles of the diluted antibody. |
