|
Cat. No. |
HAVCR1-45H
|
|
Product
Overview |
Recombinant
Human Hepatitis A Virus Cellular Receptor 1, Fc-Tagged expressed
in human cells comprises 278 amino acids and predicts a
molecular mass of 30 kDa. It migrates with the molecular weight
in the range of 50-70 kDa in SDS-PAGE under reducing conditions
due to glycosylation |
|
Description |
TIM-1 (T cell-immunoglobulin-mucin;
also KIM-1 and HAVcr-1) is a 100 kDa, type I transmembrane
glycoprotein member of the TIM family of immunoglobulin
superfamily molecules.1 - 3 This gene family is involved in the
regulation of Th1 and Th2-cell-mediated immunity. Human TIM-1 is
synthesized as a 359 amino acid (aa) precursor that contains a
20 aa signal sequence, a 270 aa extracellular domain (ECD), a 21
aa transmembrane segment and a 48 aa cytoplasmic domain.4 - 6
The ECD contains one V-type Ig-like domain and a mucin region
characterized by multiple PTTTTL motifs. The mucin region
undergoes extensive O-linked glycosylation.
A DNA sequence
encoding the mature form of human KIM1 extracellular domain
(NP_002412.1) (Ser 21-Gly 290 ) with a C-terminal polyhistidine
tag was expressed and purified after removal of the N-terminal
Fc region of human IgG1. |
|
Predicted N
terminal |
Ser 21 |
|
Purity |
> 90%, as
determined by SDS-PAGE |
|
Formulation |
Supplied as a
0.2μm filtered solution of 50mM Tris, 100mM NaCl, pH8.0 |
|
Reconstitution |
Follow the
instructions on the vial. Centrifuge the vial at 4¡æ before
opening to recover the entire contents. |
|
Endotoxin |
< 1.0 EU per
1ug cytokine as determined by the LAL method |
|
Stability |
Samples are
stable for up to twelve months from date of receipt -70 |
|
Storage |
Store it under
sterile conditions at -70¡æ. It is recommended that the protein
be aliquoted for optimal storage and be used as soon as
possible. Avoid repeated freeze-thaw cycles. |
|
Gene
Information
|
Gene Name |
HAVCR1 |
|
Synonyms |
HAVCR; HAVCR-1;
HAVcr-1; KIM-1; KIM1; TIM; TIM-1; TIM1; TIMD1; TIMD-1; T cell
immunoglobin domain and mucin domain protein 1; kidney injury
molecule 1; T cell immunoglobin domain and mucin domain protein
1; T-cell membrane protein 1; hepatitis A virus cellular
receptor 1; HAVCR1; hepatitis A virus cellular receptor 1;
HAVCR1 |
|
GeneID |
26762
|
|
mRNA Refseq |
NM_012206 |
|
Protein Refseq |
NP_036338 |
|
MIM |
606518
|
|
UniProt ID |
Q96D42 |
|
Chromosome
Location |
5q33.2 |
|
Function |
receptor
activity |
|
|
Download Datasheet:
|
|
Abbr.: 
