|
Cat. No. |
CAB411 |
|
Antigen
Information |
The protein
encoded by this gene is a cytokine that regulates T and natural
killer cell activation and proliferation. This cytokine and
interleukine 2 share many biological activities. They are found
to bind common hematopoietin receptor subunits, and may compete
for the same receptor, and thus negatively regulate each other's
activity. The number of CD8+ memory cells is shown to be
controlled by a balance between this cytokine and IL2. This
cytokine induces the activation of JAK kinases, as well as the
phosphorylation and activation of transcription activators
STAT3, STAT5, and STAT6. Studies of the mouse counterpart
suggested that this cytokine may increase the expression of
apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the
transcription activation activity of STAT6, and thus prevent
apoptosis. Two alternatively spliced transcript variants of this
gene encoding the same protein have been reported. |
|
Immunogen |
r.Human IL-15. |
|
Ig Subclass |
Mouse IgG1. |
|
Purification
Method |
Ion exchange. |
|
Protein
Concentration |
1mg/ml in PBS
(after reconstitution). |
|
Titer |
By direct
ELISA, 1:20,000 dilution will yield >1.0 O.D using alkaline
phosphatase conjugated rabbit anti-mouse Ig (Jackson
Laboratories). |
|
Applications |
Direct ELISA,
Western Blot, Immuneprecipitation, Immunohistochemistry. |
|
Shipping
Conditions |
Antibody is
shipped lyophilized at ambient temperature. |
|
Stability /
Shelf Life |
Two years lyophilized, one month in
solution at 4℃. |
|
Reconstitution |
Reconstitute
with sterile H2O. Mix gently, wash the sides of the vial and
wait 30-60 seconds before use. |
|
Storage |
In lyophilized
form, for long periods, store at 4℃
in a dry environment. After reconstitution, if not intended for
use within a month, aliquot and store at -20℃. |
|
Gene
Information
|
Gene Name |
IL15 interleukin 15 [ Homo sapiens ] |
|
Synonyms
|
IL-15; MGC9721;
Interleukin-15 prec-ursor; IL15; OTTHUMP00000164617; interleukin
15 |
|
GeneID |
3600 |
|
mRNA Refseq |
NM_000585 |
|
Protein Refseq |
NP_000576 |
|
MIM |
600554 |
|
UniProt ID |
P40933 |
|
Chromosome
Location |
4q31 |
|
Pathway |
Cytokine-cytokine receptor interaction; Jak-STAT signaling
pathway |
|
Function |
hematopoietin/interferon-class; cytoki-ne receptor binding;
protein binding;signal transducer activity |
|
|
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|
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Abbr.: 
