Mouse Anti-Human Triiodothyronine Monoclonal Antibody   [ Back  ]                         Price Inquiry

Cat. No.

CAB036

Antigen information

Triiodothyronine, C15H12I3NO4, also known as T3, is a thyroid hormone.Thyroid-stimulating hormone (TSH) activates the production of thyroxine (T4) and T3. This process is under regulation. In the hypothalamus, T4 is converted to T3. TSH is inhibited mainly by T3. The thyroid gland releases greater amounts of T4 than T3, so plasma concentrations of T4 are 40-fold higher than those of T3. Most of the circulating T3 is formed peripherally by deiodination of T4 (85%), a process that involves the removal of iodine from carbon 5 on the outer ring of T4. Thus, T4 acts as prohormone for T3.This thyroid hormone is similar to thyroxine but with one fewer iodine atoms per molecule. In addition, T3 exhibits greater activity and is produced in smaller quantity.It is the most powerful thyroid hormone, and affects almost every process in the body, including body temperature, growth, and heart rate.

Synonyms

(2S)-2-amino-3- [4-(4-hydroxy-3-iodo-phenoxy)- 3,5-diiodo-phenyl]propanoic acid; triiodothyronine; T3; 3,3',5-triiodo-L-thyronine

CAS number

6893-02-3

Molecular formula

C15H12I3NO4

Molar mass

650.9776 g mol−1

Specificity

Cross-reactivity: T3 100%; T4 <0.28%

Clone

ML01T003

Host Animal

Mouse

Isotope

IgG1, kappa

Source

Ascites

Format

Purified, Liquid

Purification

>95% pure (SDS-PAGE). Protein A chromatography Product is 0.2μm filtered.

Concentration

2.0mg/ml (OD280nm, E0.1% = 1.4)

Affinity Constant

5 x 109 L/m

Buffer

10mM Phosphate, pH 7.4 containing 150mM Sodium chloride

Preservative

None

Applications

Specific methodologies have not been tested using this product.

Storage

Short term (up to 7 days) store at 2-8°C. Long term, aliquot and store at <-40°C.