|
Cat. No. |
CAB348 |
|
Antigen
Information |
E-Selectin
belongs to a family of divalent cation-dependent
carbohydrate-binding glycoproteins or adhesion molecules. CD62E
is expressed on the surface of endothelial cells and mediates
the interaction of leukocytes and platelets with endothelial
cells during an inflammatory response. CD62E is found in
cytokine-stimulated endothelial cells and is accountable for the
accumulation of blood leukocytes at sites of inflammation by
mediating the adhesion of cells to the vascular lining. It
demonstrates structural features such as the existence of lectin-
and EGF-like domains followed by short consensus repeat (SCR)
domains that contain 6 conserved cysteine residues. E-Selectin
participates in the interaction between leukocytes and the
endothelium and appears to be involved in the pathogenesis of
atherosclerosis. |
|
Immunogen |
Purified,
Activated T-Cells. |
|
Ig Subclass |
Mouse IgG1. |
|
Purification
Method |
Ion exchange
column. |
|
Protein
Concentration |
1mg/ml in PBS
(after reconstitution). |
|
Antibody
Properties |
Staining
antibody. For staining, use 10µl/106 cells. |
|
Reconstitution |
Reconstitute
with of H2O. Mix gently, wash the sides of the vial and wait
30-60 seconds before use. |
|
Stability /
Shelf Life |
Two years
lyophilized, one month in solution at 4oC. |
|
Storage
Procedures |
Lyophilized:
store at 4oC. After reconstitution, if not intended for use
within a month, aliquot and store at -20oC. |
|
Gene
Information
|
Gene Name |
SELE selectin E [ Homo sapiens ] |
|
Synonyms
|
SELE; selectin
E; ELAM; ESEL; CD62E; ELAM1; LECAM2; ELAM-1; OTTHUMP00000032745;
CD62 antigen-like family member E; CD62E antigen; Endothelial
leukocyte adhesion molecule 1; Leukocyte-endothelial cell
adhesion molecule 2; endothelial adhesion molecule 1; leukocyte
endothelial cell adhesion molecule 2 |
|
GeneID |
6401 |
|
mRNA Refseq |
NM_000450 |
|
Protein Refseq |
NP_000441 |
|
MIM |
131210 |
|
UniProt ID |
P16581 |
|
Chromosome
Location |
1q22-q25 |
|
Pathway |
Cell adhesion
molecules (CAMs) |
|
Function |
oligosaccharide
binding; phospholipase binding; protein binding; protein
binding; sialic acid binding; sugar binding; transmembrane
receptor activity |
|
PDB rendering based on 1esl.
|
Download Datasheet:
|
|
Abbr.: 
