|
Cat. No. |
CAB346 |
|
Antigen
Information |
Basic
fibroblast growth factor is a member of the fibroblast growth
factor (FGF) family. FGF family members possess broad mitogenic
and cell survival activities, and are involved in a variety of
biological processes, including embryonic development, cell
growth, morphogenesis, tissue repair, tumor growth and invasion.
This protein functions as a modifier of endothelial cell
migration and proliferation, as well as an angiogenic factor. It
acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived
cells in vitro, thus is thought to be involved in organogenesis.
Three alternatively spliced variants encoding different isoforms
have been described. The heparin-binding growth factors are
angiogenic agents in vivo and are potent mitogens for a variety
of cell types in vitro. There are differences in the tissue
distribution and concentration of these 2 growth factors. |
|
Immunogen |
r.Human FGF-b. |
|
Ig Subclass |
Mouse IgM. |
|
Purification
Method |
Ion exchange. |
|
Protein
Concentration |
1mg/ml in PBS
(after reconstitution). |
|
Applications |
Direct ELISA,
Western Blot, Immuneprecipitation. |
|
Shipping
Conditions |
Antibody is
shipped lyophilized at ambient temperature. |
|
Titer |
By direct
ELISA, 1:10,000 dilution will yield 0.8 O.D using alkaline
phosphatase conjugated rabbit anti-mouse Ig (Jackson
Laboratories). |
|
Reconstitution |
Reconstitute
with sterile H2O. Mix gently, wash the sides of the vial and
wait 30-60 seconds before use. |
|
Stability /
Shelf Life |
Two years
lyophilized, one month in solution at 4oC. |
|
Storage
Procedures |
In lyophilized
form, for long periods, store at 4oC in a dry environment. After
reconstitution, if not intended for use within a month, aliquot
and store at -20oC. |
|
Gene
Information
|
Gene Name |
FGF2 fibroblast growth factor 2 (basic) [ Homo sapiens ] |
|
Synonyms
|
FGF2;
fibroblast growth factor 2 (basic); BFGF; FGFB; HBGF-2;
Heparin-binding growth factor 2;
Basic fibroblast growth factor;
prostatropin; basic fibroblast growth factor Bfgf;
fibroblast growth factor 2; heparin-binding growth factor |
|
GeneID |
2247 |
|
mRNA Refseq |
NM_002006 |
|
Protein Refseq |
NP_001997 |
|
MIM |
134920 |
|
UniProt ID |
P09038 |
|
Chromosome
Location |
4q26-q27 |
|
Pathway |
MAPK signaling
pathway; Melanoma; Pathways in cancer; Regulation of actin
cytoskeleton; Signaling by FGFR |
|
Function |
growth factor
activity; heparin binding; protein binding; voltage-gated
calcium channel activity |
|
PDB rendering based on 1bas.
|
Download Datasheet:
|
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Abbr.: 
